Preoperative cardiac structural changes are associated with subcortical nuclei changes and neurocognition in preschool-aged children with tetralogy of Fallot after corrective surgery
Abstract Background: Neurocognitive disorders are common in cyanotic congenital heart disease (CCHD). Preoperative cardiac structural changes have been known to cause hemodynamic abnormalities that lead to a series of events including hypoxia episodes, brain abscesses, atrial fibrillation and cerebrovascular accidents neurodevelopmental outcomes. We aimed to evaluate subcortical nuclei changes and neurocognition following corrective surgery in tetralogy of Fallot (TOF) children and analyze their relationship with preoperative cardiac structural changes. Methods: In this study, thirty-six repaired TOF children and twenty-nine healthy children (HC) were recruited. Three-dimensional (3D) T1-weighted high-resolution structural images and the Wechsler preschool and primary scale of intelligence-Fourth edition (WPPSI-Ⅳ) were used to assess the cognitions between children with TOF and HCs. Results: Significant subcortical nuclei differences were found in the left amygdala nucleus (LAM), left thalamus proper nucleus (LTHA) and right thalamus proper nucleus (RTHA) between children with TOF and HC. Impaired left amygdala nucleus integrity which was inversely related to the size of the preoperative VSD, was correlated with the working memory index in TOF. Conclusions: This study demonstrated subcortical nuclei structure injury possibly caused by cardiac abnormal anatomical malformations, and this injury is related to worse working memory performance in preschool-aged children with TOF. These findings suggested that LAM may be a potential biomarker of neurocognitive impairments in TOF and can be used to predict future neurodevelopmental outcomes, which also provide new insights into the underlying neurophysiological mechanisms of neurocognitive impairments in TOF..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
ResearchSquare.com - (2024) vom: 13. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hu, Liang [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-3992117/v1 |
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XRA042903173 |
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| 245 | 1 | 0 | |a Preoperative cardiac structural changes are associated with subcortical nuclei changes and neurocognition in preschool-aged children with tetralogy of Fallot after corrective surgery |
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| 520 | |a Abstract Background: Neurocognitive disorders are common in cyanotic congenital heart disease (CCHD). Preoperative cardiac structural changes have been known to cause hemodynamic abnormalities that lead to a series of events including hypoxia episodes, brain abscesses, atrial fibrillation and cerebrovascular accidents neurodevelopmental outcomes. We aimed to evaluate subcortical nuclei changes and neurocognition following corrective surgery in tetralogy of Fallot (TOF) children and analyze their relationship with preoperative cardiac structural changes. Methods: In this study, thirty-six repaired TOF children and twenty-nine healthy children (HC) were recruited. Three-dimensional (3D) T1-weighted high-resolution structural images and the Wechsler preschool and primary scale of intelligence-Fourth edition (WPPSI-Ⅳ) were used to assess the cognitions between children with TOF and HCs. Results: Significant subcortical nuclei differences were found in the left amygdala nucleus (LAM), left thalamus proper nucleus (LTHA) and right thalamus proper nucleus (RTHA) between children with TOF and HC. Impaired left amygdala nucleus integrity which was inversely related to the size of the preoperative VSD, was correlated with the working memory index in TOF. Conclusions: This study demonstrated subcortical nuclei structure injury possibly caused by cardiac abnormal anatomical malformations, and this injury is related to worse working memory performance in preschool-aged children with TOF. These findings suggested that LAM may be a potential biomarker of neurocognitive impairments in TOF and can be used to predict future neurodevelopmental outcomes, which also provide new insights into the underlying neurophysiological mechanisms of neurocognitive impairments in TOF. | ||
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| 700 | 1 | |a Li, Huijun |4 aut | |
| 700 | 1 | |a Zhu, Meijiao |4 aut | |
| 700 | 1 | |a Zhang, Yaqi |4 aut | |
| 700 | 1 | |a Fu, Mingcui |4 aut | |
| 700 | 1 | |a Tang, Minghui |4 aut | |
| 700 | 1 | |a Lu, Fan |4 aut | |
| 700 | 1 | |a Cai, Xinyu |4 aut | |
| 700 | 1 | |a An, Jia |4 aut | |
| 700 | 1 | |a Patel, Nishant |4 aut | |
| 700 | 1 | |a Lin, Ye |4 aut | |
| 700 | 1 | |a Zhang, Zhen |4 aut | |
| 700 | 1 | |a Yang, Ming |4 aut | |
| 700 | 1 | |a Mo, Xuming |0 (orcid)0000-0002-2264-6123 |4 aut | |
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