The Efficacy of L-glutamine in Osteoarthritis:a comparative analysis with celecoxib and glucosamine sulfate.
Abstract Objective: to explore the therapeutic efficacy of L-glutamine (L-Gln) in osteoarthritis(OA), and compare with glucosamine sulfate (GS), and celecoxib (CXB). Methods: Male SD rats were administered sodium chloride, L-Gln, GS, or CXB via gavage for eight weeks starting in the fifth week after operation. Then the severity of knee OA in rats was evaluated by serological analysis, histological examination and imaging examination. Patients with mild OA were administered L-Gln, GS, or CXB orally for 12 weeks in accordance with the randomization principle. Efficacy end points were the change from baseline to week 24 in the pain and physical function subscale scores of the Western Ontario and McMaster Universities OA Index (WOMAC), and Lequesne score. Results: The treatment with L-Gln and two other drugs alleviated the increased concentration of serum cartilage degradation markers, cartilage destruction, osteophyte formation, and loss of subchondral bone mass caused by OA in rats. During follow-up, the WOMAC pain and physical function subscale scores and Lequesne score of all three groups of patients decreased from baseline and exceeded the minimum clinical difference. The results indicate that the therapeutic effect of L-Gln is comparable to the other two drugs, and in some indicators, it may even be superior to them. Conclusion: Our research indicates that L-Gln is comparable to GS and CXB in improving the pathological progression and clinical efficacy of OA. However, L-Gln has a lower occurrence of gastrointestinal adverse reactions and effectively alleviates knee joint pain in OA patients who are unresponsive to NSAIDs and GS. This makes it a promising drug for the treatment of osteoarthritis..
| Medienart: |
|
|---|
Preprint| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
ResearchSquare.com - (2024) vom: 21. Apr. Zur Gesamtaufnahme - year:2024 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Cheng, Wendan [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.21203/rs.3.rs-3986159/v1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
XRA042869110 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | XRA042869110 | ||
| 003 | DE-627 | ||
| 005 | 20240421130809.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240312s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.21203/rs.3.rs-3986159/v1 |2 doi | |
| 035 | |a (DE-627)XRA042869110 | ||
| 035 | |a (ResearchSquare)10.21203/rs.3.rs-3986159/v1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Cheng, Wendan |e verfasserin |0 (orcid)0000-0002-4182-7202 |4 aut | |
| 245 | 1 | 0 | |a The Efficacy of L-glutamine in Osteoarthritis:a comparative analysis with celecoxib and glucosamine sulfate. |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract Objective: to explore the therapeutic efficacy of L-glutamine (L-Gln) in osteoarthritis(OA), and compare with glucosamine sulfate (GS), and celecoxib (CXB). Methods: Male SD rats were administered sodium chloride, L-Gln, GS, or CXB via gavage for eight weeks starting in the fifth week after operation. Then the severity of knee OA in rats was evaluated by serological analysis, histological examination and imaging examination. Patients with mild OA were administered L-Gln, GS, or CXB orally for 12 weeks in accordance with the randomization principle. Efficacy end points were the change from baseline to week 24 in the pain and physical function subscale scores of the Western Ontario and McMaster Universities OA Index (WOMAC), and Lequesne score. Results: The treatment with L-Gln and two other drugs alleviated the increased concentration of serum cartilage degradation markers, cartilage destruction, osteophyte formation, and loss of subchondral bone mass caused by OA in rats. During follow-up, the WOMAC pain and physical function subscale scores and Lequesne score of all three groups of patients decreased from baseline and exceeded the minimum clinical difference. The results indicate that the therapeutic effect of L-Gln is comparable to the other two drugs, and in some indicators, it may even be superior to them. Conclusion: Our research indicates that L-Gln is comparable to GS and CXB in improving the pathological progression and clinical efficacy of OA. However, L-Gln has a lower occurrence of gastrointestinal adverse reactions and effectively alleviates knee joint pain in OA patients who are unresponsive to NSAIDs and GS. This makes it a promising drug for the treatment of osteoarthritis. | ||
| 650 | 4 | |a Biology |7 (dpeaa)DE-84 | |
| 650 | 4 | |a 570 |7 (dpeaa)DE-84 | |
| 700 | 1 | |a Hu, Zhongyao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Changming |e verfasserin |4 aut | |
| 700 | 1 | |a wang, chen |e verfasserin |4 aut | |
| 700 | 1 | |a He, Junyan |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Yiqun |e verfasserin |4 aut | |
| 700 | 1 | |a xu, Zelin |e verfasserin |4 aut | |
| 700 | 1 | |a yu, Yangmang |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Chun |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Haoran |e verfasserin |4 aut | |
| 700 | 1 | |a Jing, Juehua |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Ya |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Huan |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Miao |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t ResearchSquare.com |g (2024) vom: 21. Apr. |
| 773 | 1 | 8 | |g year:2024 |g day:21 |g month:04 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.21203/rs.3.rs-3986159/v1 |x 0 |z kostenfrei |3 Volltext |
| 912 | |a GBV_XRA | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 21 |c 04 | ||