The Cortical Asymmetry Index (CAI) for subtyping dementia patients
Abstract Background: Frontotemporal dementia (FTD) patients usually show more asymmetric atrophy patterns than Alzheimer’s Disease (AD) patients. Here, we define the individual Cortical Asymmetry Index (CAI) and explore its diagnostic utility. Methods: We collected structural T1-MRI scans from 554 participants, including FTD (different phenotypes), AD, and healthy controls, and processed them using Freesurfer. We defined the CAI using measures based on a metric derived from information theory with the cortical thickness measures. Different subsets of the study participants had additional follow-up MRIs, cerebrospinal fluid (CSF), or plasma measures. We analyzed differences at cross-sectional and longitudinal levels. We then clustered FTD and AD participants based on the CAI values and studied the patients’ fluid biomarker characteristics within each cluster. Results: CAI differentiated FTD, AD, and healthy controls. It also distinguished the semantic variant Primary Progressive Aphasia (svPPA) from the other FTD phenotypes. In FTD, the CAI increased over time. The cluster analysis identified two subgroups within FTD, characterized by different CSF and plasma neurofilament-light (NfL) levels, and two subgroups within AD, with different plasma Glial fibrillary acidic protein (GFAP) levels. In AD, CAI correlated with plasma-GFAP and Mini-Mental State Examination (MMSE); in FTD, the CAI was associated with NfL levels (CSF and plasma. Conclusions: The method proposed here is able to quantify asymmetries previously described visually. The CAI could define clinically and biologically meaningful disease subgroups. We highlight the potential clinical utility of CAI in the differential diagnosis between FTD and AD and the different FTD phenotypes..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
ResearchSquare.com - (2024) vom: 05. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Pérez-Millan, Agnès [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-3982839/v1 |
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XRA042804906 |
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| 520 | |a Abstract Background: Frontotemporal dementia (FTD) patients usually show more asymmetric atrophy patterns than Alzheimer’s Disease (AD) patients. Here, we define the individual Cortical Asymmetry Index (CAI) and explore its diagnostic utility. Methods: We collected structural T1-MRI scans from 554 participants, including FTD (different phenotypes), AD, and healthy controls, and processed them using Freesurfer. We defined the CAI using measures based on a metric derived from information theory with the cortical thickness measures. Different subsets of the study participants had additional follow-up MRIs, cerebrospinal fluid (CSF), or plasma measures. We analyzed differences at cross-sectional and longitudinal levels. We then clustered FTD and AD participants based on the CAI values and studied the patients’ fluid biomarker characteristics within each cluster. Results: CAI differentiated FTD, AD, and healthy controls. It also distinguished the semantic variant Primary Progressive Aphasia (svPPA) from the other FTD phenotypes. In FTD, the CAI increased over time. The cluster analysis identified two subgroups within FTD, characterized by different CSF and plasma neurofilament-light (NfL) levels, and two subgroups within AD, with different plasma Glial fibrillary acidic protein (GFAP) levels. In AD, CAI correlated with plasma-GFAP and Mini-Mental State Examination (MMSE); in FTD, the CAI was associated with NfL levels (CSF and plasma. Conclusions: The method proposed here is able to quantify asymmetries previously described visually. The CAI could define clinically and biologically meaningful disease subgroups. We highlight the potential clinical utility of CAI in the differential diagnosis between FTD and AD and the different FTD phenotypes. | ||
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| 700 | 1 | |a Estrada, Uma Maria Lal-Trehan |4 aut | |
| 700 | 1 | |a Falgàs, Neus |4 aut | |
| 700 | 1 | |a Guillén, Núria |4 aut | |
| 700 | 1 | |a Borrego-Écija, Sergi |4 aut | |
| 700 | 1 | |a Juncà-Parella, Jordi |4 aut | |
| 700 | 1 | |a Bosch, Beatriz |4 aut | |
| 700 | 1 | |a Tort-Merino, Adrià |4 aut | |
| 700 | 1 | |a Sarto, Jordi |4 aut | |
| 700 | 1 | |a Augé, Josep Maria |4 aut | |
| 700 | 1 | |a Antonell, Anna |4 aut | |
| 700 | 1 | |a Bargalló, Nuria |4 aut | |
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| 700 | 1 | |a Naranjo, Laura |4 aut | |
| 700 | 1 | |a Balasa, Mircea |4 aut | |
| 700 | 1 | |a Lladó, Albert |4 aut | |
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