Trends and predictors of changes in renal function after radical nephrecto my for renal tumors
Abstract Background: Chronic kidney disease (CKD) is a common postoperative complication in patients who undergo radical nephrectomy for renal tumours. However, the factors influencing long-term renal function require further investigation. Objective: This study aimed to investigate the trends in renal function changes and risk factors for renal function deterioration in patients with renal tumours after radical nephrectomy. Results: We analysed the data from 329 patients with renal tumours undergoing radical nephrectomies between January 2013 and December 2018. We monitored the changes in the patient’s renal function before and after surgery for 3 years. The progression of renal function was determined by the progression and degradation of CKD stages. Univariate and multivariate logistic regression analyses were used to analyse the causes of renal function progression. In this study, 43.7% of patients had postoperative acute kidney injury (AKI) and 48.3% had upgraded CKD stages. Further research revealed that the patient’s renal function levelled off 3 months following surgery. Additionally, renal function changes during these 3 months have a substantial impact on the progression of long-term renal function in patients. Conclusion: AKI may be an indicator of short-term postoperative changes in renal function. Renal function tests should be performed in patients with AKI after radical nephrectomy to monitor the progression of functional impairment, particularly within the first 3 months after radical nephrectomy..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
ResearchSquare.com - (2024) vom: 05. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yan, Yongchao [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-3988482/v1 |
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| 520 | |a Abstract Background: Chronic kidney disease (CKD) is a common postoperative complication in patients who undergo radical nephrectomy for renal tumours. However, the factors influencing long-term renal function require further investigation. Objective: This study aimed to investigate the trends in renal function changes and risk factors for renal function deterioration in patients with renal tumours after radical nephrectomy. Results: We analysed the data from 329 patients with renal tumours undergoing radical nephrectomies between January 2013 and December 2018. We monitored the changes in the patient’s renal function before and after surgery for 3 years. The progression of renal function was determined by the progression and degradation of CKD stages. Univariate and multivariate logistic regression analyses were used to analyse the causes of renal function progression. In this study, 43.7% of patients had postoperative acute kidney injury (AKI) and 48.3% had upgraded CKD stages. Further research revealed that the patient’s renal function levelled off 3 months following surgery. Additionally, renal function changes during these 3 months have a substantial impact on the progression of long-term renal function in patients. Conclusion: AKI may be an indicator of short-term postoperative changes in renal function. Renal function tests should be performed in patients with AKI after radical nephrectomy to monitor the progression of functional impairment, particularly within the first 3 months after radical nephrectomy. | ||
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