1-(4-aminophenyl)-3-morpholinopiperidin-2-one: A new process related impurity of Apixaban- An anticoagulant drug
Abstract In this report, we describe the identification of new process related impurity observed during the preparation of Apixaban-An anticoagulant drug. As a part of the investigation, we isolated the impurity by column chromatography with > 96% purity and analyzed the sample of impurity by LC-MS, IR and NMR spectroscopy. The LC-MS analysis coupled with IR and NMR analysis suggested that the impurity is 1-(4-aminophenyl)-3-morpholinopiperidin-2-one, generated during preparation of Apixaban intermediate (APN-05). The impurity is a reduced form of APN-05 possibly formed due to reduction of ring double bond of dihydropyridin-2(1H)-one moiety of APN-05..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
ResearchSquare.com - (2024) vom: 13. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kumar, Vipin [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-3992931/v1 |
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| 520 | |a Abstract In this report, we describe the identification of new process related impurity observed during the preparation of Apixaban-An anticoagulant drug. As a part of the investigation, we isolated the impurity by column chromatography with > 96% purity and analyzed the sample of impurity by LC-MS, IR and NMR spectroscopy. The LC-MS analysis coupled with IR and NMR analysis suggested that the impurity is 1-(4-aminophenyl)-3-morpholinopiperidin-2-one, generated during preparation of Apixaban intermediate (APN-05). The impurity is a reduced form of APN-05 possibly formed due to reduction of ring double bond of dihydropyridin-2(1H)-one moiety of APN-05. | ||
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| 700 | 1 | |a Sharma, Sachin Kumar |4 aut | |
| 700 | 1 | |a Singh, Govind |4 aut | |
| 700 | 1 | |a Dhuriya, Shyambaran |4 aut | |
| 700 | 1 | |a Balthu, Lingaiah |4 aut | |
| 700 | 1 | |a Kumar, Sushil |4 aut | |
| 700 | 1 | |a Devi, Rashmi |4 aut | |
| 700 | 1 | |a Yadav, Krishna Kumar |4 aut | |
| 700 | 1 | |a Chourasiya, Sumit S. |4 aut | |
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