Post-viral symptoms and conditions are more frequent in COVID-19 than influenza, but not more persistent
Abstract Post-viral symptoms have long been known in the medical community but have received more public attention during the COVID-19 pandemic. Many post-viral symptoms were reported as particularly frequent after SARS-CoV-2 infection. However, there is still a lack of evidence regarding the specificity, frequency and persistence of these symptoms in comparison to other viral infectious diseases such as Influenza. We addressed this topic by investigating a large population-based cohort based on German routine healthcare data. We matched 573,791 individuals with a PCR-test confirmed SARS-CoV-2 infection from the year 2020 to contemporary controls without SARS-CoV-2 infection and controls from the last Influenza outbreak in 2018 and followed them up to 18 months. We found that post-viral symptoms as defined for COVID-19 by the WHO as well as tissue damage were more frequent among the COVID-19 cohort than the Influenza cohort. Persistence of post-viral symptoms was however similar between COVID-19 and Influenza. We conclude that post-viral symptoms following SARS-CoV-2 infection constitute a substantial disease burden as they are frequent and often persist for many months. As COVID-19 is becoming endemic, the disease must not be trivialized. Research should focus on the development of effective treatments for post-viral symptoms..
| Medienart: |
|
|---|
Preprint| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
ResearchSquare.com - (2024) vom: 08. Feb. Zur Gesamtaufnahme - year:2024 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Tesch, Falko [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.21203/rs.3.rs-3870058/v1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
XRA04242481X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | XRA04242481X | ||
| 003 | DE-627 | ||
| 005 | 20240209130744.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240207s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.21203/rs.3.rs-3870058/v1 |2 doi | |
| 035 | |a (DE-627)XRA04242481X | ||
| 035 | |a (ResearchSquare)10.21203/rs.3.rs-3870058/v1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Tesch, Falko |e verfasserin |0 (orcid)0000-0001-8933-643X |4 aut | |
| 245 | 1 | 0 | |a Post-viral symptoms and conditions are more frequent in COVID-19 than influenza, but not more persistent |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract Post-viral symptoms have long been known in the medical community but have received more public attention during the COVID-19 pandemic. Many post-viral symptoms were reported as particularly frequent after SARS-CoV-2 infection. However, there is still a lack of evidence regarding the specificity, frequency and persistence of these symptoms in comparison to other viral infectious diseases such as Influenza. We addressed this topic by investigating a large population-based cohort based on German routine healthcare data. We matched 573,791 individuals with a PCR-test confirmed SARS-CoV-2 infection from the year 2020 to contemporary controls without SARS-CoV-2 infection and controls from the last Influenza outbreak in 2018 and followed them up to 18 months. We found that post-viral symptoms as defined for COVID-19 by the WHO as well as tissue damage were more frequent among the COVID-19 cohort than the Influenza cohort. Persistence of post-viral symptoms was however similar between COVID-19 and Influenza. We conclude that post-viral symptoms following SARS-CoV-2 infection constitute a substantial disease burden as they are frequent and often persist for many months. As COVID-19 is becoming endemic, the disease must not be trivialized. Research should focus on the development of effective treatments for post-viral symptoms. | ||
| 650 | 4 | |a Biology |7 (dpeaa)DE-84 | |
| 650 | 4 | |a 570 |7 (dpeaa)DE-84 | |
| 700 | 1 | |a Ehm, Franz |0 (orcid)0000-0003-3749-4000 |4 aut | |
| 700 | 1 | |a Loser, Friedrich |4 aut | |
| 700 | 1 | |a Vivirito, Annika |4 aut | |
| 700 | 1 | |a Wende, Danny |0 (orcid)0000-0002-0545-0807 |4 aut | |
| 700 | 1 | |a Batram, Manuel |4 aut | |
| 700 | 1 | |a Bechmann, Lars |4 aut | |
| 700 | 1 | |a Buschmann, Tilo |4 aut | |
| 700 | 1 | |a Menzer, Simone |4 aut | |
| 700 | 1 | |a Ludwig, Marion |4 aut | |
| 700 | 1 | |a Roessler, Martin |0 (orcid)0000-0002-4662-4156 |4 aut | |
| 700 | 1 | |a Seifert, Martin |4 aut | |
| 700 | 1 | |a Margolis, Giselle Sarganas |4 aut | |
| 700 | 1 | |a Reitzle, Lukas |4 aut | |
| 700 | 1 | |a König, Christina |4 aut | |
| 700 | 1 | |a Schulte, Claudia |4 aut | |
| 700 | 1 | |a Hertle, Dagmar |0 (orcid)0000-0002-5645-0655 |4 aut | |
| 700 | 1 | |a Ballesteros, Pedro |4 aut | |
| 700 | 1 | |a Baßler, Stefan |4 aut | |
| 700 | 1 | |a Bertele, Barbara |4 aut | |
| 700 | 1 | |a Bitterer, Thomas |4 aut | |
| 700 | 1 | |a Riederer, Cordula |4 aut | |
| 700 | 1 | |a Sobik, Franziska |4 aut | |
| 700 | 1 | |a Scheidt-Nave, Christa |4 aut | |
| 700 | 1 | |a Schmitt, Jochen |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t ResearchSquare.com |g (2024) vom: 08. Feb. |
| 773 | 1 | 8 | |g year:2024 |g day:08 |g month:02 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.21203/rs.3.rs-3870058/v1 |z kostenfrei |3 Volltext |
| 912 | |a GBV_XRA | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 08 |c 02 | ||