Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV- 2 variants delta and omicron - results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP)
Abstract <jats:underline>Purpose</jats:underline> The influence of new SARS-CoV-2 variants on the post-COVID-19 condition (PCC) remains unanswered. Therefore, we examined the prevalence and predictors of PCC-related symptoms in patients infected with the SARS-CoV-2 variants delta or omicron. <jats:underline>Methods</jats:underline> We compared prevalences and risk factors of acute and PCC-related symptoms three months after primary infection (3MFU) between delta- and omicron-infected patients from the Cross-Sectoral Platform of the German National Pandemic Cohort Network. Health-related quality of life (HrQoL) was determined by the EQ-5D-5L index score and trend groups were calculated to describe changes of HrQoL between different time points. <jats:underline>Results</jats:underline> We considered 758 patients for our analysis (delta: n = 341; omicron: n = 417). Compared with omicron patients, delta patients had a similar prevalence of PCC at the 3MFU (p = 0.354), whereby fatigue occurred most frequently (n = 256, 34%). HrQoL was comparable between the groups with the lowest EQ-5D-5L index score (0.75, 95%-CI 0.73-0.78) at disease onset. While most patients (69%, n = 348) never showed a declined HrQoL, it deteriorated substantially in 37 patients (7%) from the acute phase to the 3MFU of which 27 were infected with omicron. <jats:underline>Conclusion</jats:underline> With quality-controlled data from a multicenter cohort, we showed that PCC is an equally common challenge for patients infected with the SARS-CoV-2 variants delta and omicron at least for the German population. Developing the EQ-5D-5L index score trend groups showed that over two thirds of patients did not experience any restrictions in their HrQoL due to or after the SARS-CoV-2 infection at the 3MFU. The cohort is registered at ClinicalTrials.gov since February 24, 2021 (Identifier: NCT04768998)..
Medienart: |
Preprint |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
ResearchSquare.com - (2024) vom: 10. Jan. Zur Gesamtaufnahme - year:2024 |
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Sprache: |
Englisch |
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Links: |
Volltext [kostenfrei] |
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Themen: |
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doi: |
10.21203/rs.3.rs-3845618/v1 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
XRA042130379 |
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245 | 1 | 0 | |a Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV- 2 variants delta and omicron - results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP) |
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520 | |a Abstract <jats:underline>Purpose</jats:underline> The influence of new SARS-CoV-2 variants on the post-COVID-19 condition (PCC) remains unanswered. Therefore, we examined the prevalence and predictors of PCC-related symptoms in patients infected with the SARS-CoV-2 variants delta or omicron. <jats:underline>Methods</jats:underline> We compared prevalences and risk factors of acute and PCC-related symptoms three months after primary infection (3MFU) between delta- and omicron-infected patients from the Cross-Sectoral Platform of the German National Pandemic Cohort Network. Health-related quality of life (HrQoL) was determined by the EQ-5D-5L index score and trend groups were calculated to describe changes of HrQoL between different time points. <jats:underline>Results</jats:underline> We considered 758 patients for our analysis (delta: n = 341; omicron: n = 417). Compared with omicron patients, delta patients had a similar prevalence of PCC at the 3MFU (p = 0.354), whereby fatigue occurred most frequently (n = 256, 34%). HrQoL was comparable between the groups with the lowest EQ-5D-5L index score (0.75, 95%-CI 0.73-0.78) at disease onset. While most patients (69%, n = 348) never showed a declined HrQoL, it deteriorated substantially in 37 patients (7%) from the acute phase to the 3MFU of which 27 were infected with omicron. <jats:underline>Conclusion</jats:underline> With quality-controlled data from a multicenter cohort, we showed that PCC is an equally common challenge for patients infected with the SARS-CoV-2 variants delta and omicron at least for the German population. Developing the EQ-5D-5L index score trend groups showed that over two thirds of patients did not experience any restrictions in their HrQoL due to or after the SARS-CoV-2 infection at the 3MFU. The cohort is registered at ClinicalTrials.gov since February 24, 2021 (Identifier: NCT04768998). | ||
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700 | 1 | |a Appel, Katharina S. |4 aut | |
700 | 1 | |a Miljukov, Olga |4 aut | |
700 | 1 | |a Schneider, Johannes |4 aut | |
700 | 1 | |a Addo, Marylyn M. |4 aut | |
700 | 1 | |a Bals, Robert |4 aut | |
700 | 1 | |a Bercker, Sven |4 aut | |
700 | 1 | |a Blaschke, Sabine |4 aut | |
700 | 1 | |a Bröhl, Isabel |4 aut | |
700 | 1 | |a Büchner, Nikolaus |4 aut | |
700 | 1 | |a Dashti, Hiwa |4 aut | |
700 | 1 | |a Erber, Johanna |4 aut | |
700 | 1 | |a Friedrichs, Anette |4 aut | |
700 | 1 | |a Geisler, Ramsia |4 aut | |
700 | 1 | |a Göpel, Siri |4 aut | |
700 | 1 | |a Hagen, Marina |4 aut | |
700 | 1 | |a Hanses, Frank |4 aut | |
700 | 1 | |a Jensen, Björn-Erik Ole |4 aut | |
700 | 1 | |a Keul, Maria |4 aut | |
700 | 1 | |a Krawczyk, Adalbert |4 aut | |
700 | 1 | |a Lorenz-Depiereux, Bettina |4 aut | |
700 | 1 | |a Meybohm, Patrick |4 aut | |
700 | 1 | |a Milovanovic, Milena |4 aut | |
700 | 1 | |a Mitrov, Lazar |4 aut | |
700 | 1 | |a Nürnberger, Carolin |4 aut | |
700 | 1 | |a Obst, Wilfried |4 aut | |
700 | 1 | |a Römmele, Christoph |4 aut | |
700 | 1 | |a Schäfer, Christian |4 aut | |
700 | 1 | |a Scheer, Christian |4 aut | |
700 | 1 | |a Scherer, Margarete |4 aut | |
700 | 1 | |a Schmidt, Julia |4 aut | |
700 | 1 | |a Seibel, Kristina |4 aut | |
700 | 1 | |a Sikdar, Shimita |4 aut | |
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700 | 1 | |a Tepasse, Phil-Robin |4 aut | |
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700 | 1 | |a Vehreschild, Maria J.G.T. |4 aut | |
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700 | 1 | |a Vehreschild, J. Janne |4 aut | |
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