In situ expression of TNF-α and IL-10 in human dermatophytosis lesions due to Trichophyton rubrum
Abstract Dermatophytosis is a very common superficial mycosis, but there are few studies about the human immune response to dermatophytes. We aim to analyze the in situ expression of TNF-α and IL-10 in human dermatophytosis. Expression of TNF-α and IL-10 were evaluated in skin samples from 10 patients with dermatophytosis and 12 healthy subjects using an immunohistochemistry assay. TNF-α and IL-10 were significantly elevated in lesions from patients with dermatophytosis compared to healthy controls. These data illustrate the balance of pro- and anti-inflammatory cytokines suggesting Trichophyton rubrum infection could control the local immune response..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
ResearchSquare.com - (2023) vom: 28. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Reis, Ana Paula Carvalho [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-3356212/v1 |
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| PPN (Katalog-ID): |
XRA041687574 |
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| 245 | 1 | 0 | |a In situ expression of TNF-α and IL-10 in human dermatophytosis lesions due to Trichophyton rubrum |
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| 520 | |a Abstract Dermatophytosis is a very common superficial mycosis, but there are few studies about the human immune response to dermatophytes. We aim to analyze the in situ expression of TNF-α and IL-10 in human dermatophytosis. Expression of TNF-α and IL-10 were evaluated in skin samples from 10 patients with dermatophytosis and 12 healthy subjects using an immunohistochemistry assay. TNF-α and IL-10 were significantly elevated in lesions from patients with dermatophytosis compared to healthy controls. These data illustrate the balance of pro- and anti-inflammatory cytokines suggesting Trichophyton rubrum infection could control the local immune response. | ||
| 650 | 4 | |a Biology |7 (dpeaa)DE-84 | |
| 650 | 4 | |a 570 |7 (dpeaa)DE-84 | |
| 700 | 1 | |a Correia, Franciele Fernandes |4 aut | |
| 700 | 1 | |a Celestrino, Giovanna Azevedo |4 aut | |
| 700 | 1 | |a Pagliari, Carla |4 aut | |
| 700 | 1 | |a Criado, Paulo Ricardo |4 aut | |
| 700 | 1 | |a Lalwani, Pritesh Jaychand |4 aut | |
| 700 | 1 | |a Benard, Gil |4 aut | |
| 700 | 1 | |a STAFOCKER, MARIA DA GLÓRIA SOUSA |0 (orcid)0000-0003-4157-1945 |4 aut | |
| 700 | 1 | |a Sousa, Maria Gloria Teixeira |4 aut | |
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