Later initiation of ECMO is associated with intracranial hemorrhage in COVID-19 patients
Abstract The occurrence of severe intracranial hemorrhage under venovenous extracorporeal membrane oxygenation (VV-ECMO) is a diagnostic and therapeutic challenge. The aim of this retrospective study is to determine factors associated with the occurrence of severe intracranial hemorrhage under VV-ECMO in patients with SARS-CoV-2 infection. Among the 43 COVID-19 VV-ECMO patients included (seven women, median age: 55 years), eight patients(19%) presented an intracranial hemorrhage during VV-ECMO treatment, and 10 patients didn’t show any signs of intracranial hemorrhage on brain imaging. Twenty-five patients didn’t have imaging during or after VV-ECMO treatment. Kaplan-Meier analysis showed that the delay from hospital admission to VV-ECMO initiation was longer in patients with intracranial hemorrhage than in patients without intracranial hemorrhage(log-rank test P=0.03). Minute ventilation before cannulation was significantly lower in patients with intracranial hemorrhage compared to patients without intracranial hemorrhage: median(range)= 7.7L/min (3.9–14.0) vs. 12.1L/min(8.3–16.0);P=0.04. Arterial lactate values were higher in patients with intracranial hemorrhage compared to patients without intracranial hemorrhage: median(range)= 3.0mmol/L(1.1–6.6) vs. 1.9mmol/L(1.1–2.8);P=0.03. The occurrence of intracranial hemorrhage was associated with a longer period from hospitalization to VV-ECMO initiation, as well as hypoventilation and higher arterial lactate levels before VV-ECMO treatment..
| Medienart: |
|
|---|
Preprint| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
ResearchSquare.com - (2023) vom: 20. Nov. Zur Gesamtaufnahme - year:2023 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Saiydoun, Gabriel [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.21203/rs.3.rs-3597654/v1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
XRA041604350 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | XRA041604350 | ||
| 003 | DE-627 | ||
| 005 | 20231121130853.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231121s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.21203/rs.3.rs-3597654/v1 |2 doi | |
| 035 | |a (DE-627)XRA041604350 | ||
| 035 | |a (ResearchSquare)10.21203/rs.3.rs-3597654/v1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Saiydoun, Gabriel |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Later initiation of ECMO is associated with intracranial hemorrhage in COVID-19 patients |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract The occurrence of severe intracranial hemorrhage under venovenous extracorporeal membrane oxygenation (VV-ECMO) is a diagnostic and therapeutic challenge. The aim of this retrospective study is to determine factors associated with the occurrence of severe intracranial hemorrhage under VV-ECMO in patients with SARS-CoV-2 infection. Among the 43 COVID-19 VV-ECMO patients included (seven women, median age: 55 years), eight patients(19%) presented an intracranial hemorrhage during VV-ECMO treatment, and 10 patients didn’t show any signs of intracranial hemorrhage on brain imaging. Twenty-five patients didn’t have imaging during or after VV-ECMO treatment. Kaplan-Meier analysis showed that the delay from hospital admission to VV-ECMO initiation was longer in patients with intracranial hemorrhage than in patients without intracranial hemorrhage(log-rank test P=0.03). Minute ventilation before cannulation was significantly lower in patients with intracranial hemorrhage compared to patients without intracranial hemorrhage: median(range)= 7.7L/min (3.9–14.0) vs. 12.1L/min(8.3–16.0);P=0.04. Arterial lactate values were higher in patients with intracranial hemorrhage compared to patients without intracranial hemorrhage: median(range)= 3.0mmol/L(1.1–6.6) vs. 1.9mmol/L(1.1–2.8);P=0.03. The occurrence of intracranial hemorrhage was associated with a longer period from hospitalization to VV-ECMO initiation, as well as hypoventilation and higher arterial lactate levels before VV-ECMO treatment. | ||
| 650 | 4 | |a Biology |7 (dpeaa)DE-84 | |
| 650 | 4 | |a 570 |7 (dpeaa)DE-84 | |
| 700 | 1 | |a Bapst, Blanche |4 aut | |
| 700 | 1 | |a Teiger, Emmanuel |4 aut | |
| 700 | 1 | |a Folliguet, Thierry |4 aut | |
| 700 | 1 | |a Gallet, Romain |4 aut | |
| 700 | 1 | |a Palfi, Stéphane |4 aut | |
| 700 | 1 | |a Mekantso-Dessap, Armand |4 aut | |
| 700 | 1 | |a Mongardon, Nicolas |4 aut | |
| 700 | 1 | |a Rancière, Fanny |4 aut | |
| 700 | 1 | |a Faillot, Matthieu |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t ResearchSquare.com |g (2023) vom: 20. Nov. |
| 773 | 1 | 8 | |g year:2023 |g day:20 |g month:11 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.21203/rs.3.rs-3597654/v1 |z kostenfrei |3 Volltext |
| 912 | |a GBV_XRA | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 20 |c 11 | ||