Unusual specific interaction of RBD with zeolite induces rapid neutralization of SARS-CoV-2
Abstract RBD-ACE2 interaction is critical in mediating SARS-CoV-2 attachment to its host cells. Blocking the attachment by inhibiting RBD-ACE2 binding is an effective way to prevent COVID-19 infection. In this study, we demonstrate that copper-ion exchanged zeolite (Cu-zeolite) binds specifically to RBD of SARS-CoV-2 via an unusual specific copper-content-dependent interaction of Cu-zeolite with RBD. Accordingly, Cu-zeolites prevent the virions from interacting with host cells, contributing to efficient and rapid SARS-CoV-2 neutralization. Therefore, Cu-zeolite has the potential to serve as a feasible and effective preventive measure to reduce exposure to the virus and as a therapeutic agent for post-exposure treatment of COVID-19..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
ResearchSquare.com - (2023) vom: 07. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fan, Jie [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-3162018/v1 |
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| PPN (Katalog-ID): |
XRA041471865 |
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| 520 | |a Abstract RBD-ACE2 interaction is critical in mediating SARS-CoV-2 attachment to its host cells. Blocking the attachment by inhibiting RBD-ACE2 binding is an effective way to prevent COVID-19 infection. In this study, we demonstrate that copper-ion exchanged zeolite (Cu-zeolite) binds specifically to RBD of SARS-CoV-2 via an unusual specific copper-content-dependent interaction of Cu-zeolite with RBD. Accordingly, Cu-zeolites prevent the virions from interacting with host cells, contributing to efficient and rapid SARS-CoV-2 neutralization. Therefore, Cu-zeolite has the potential to serve as a feasible and effective preventive measure to reduce exposure to the virus and as a therapeutic agent for post-exposure treatment of COVID-19. | ||
| 650 | 4 | |a Biology |7 (dpeaa)DE-84 | |
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| 700 | 1 | |a Li, Dan |4 aut | |
| 700 | 1 | |a Liu, Shenxin |4 aut | |
| 700 | 1 | |a Zhu, Miaojin |4 aut | |
| 700 | 1 | |a Zhang, Tongtong |4 aut | |
| 700 | 1 | |a Yu, Lisha |4 aut | |
| 700 | 1 | |a He, Min |4 aut | |
| 700 | 1 | |a Chen, Xutao |4 aut | |
| 700 | 1 | |a Wang, Fangjun |0 (orcid)0000-0002-8118-7019 |4 aut | |
| 700 | 1 | |a Zhang, Hang |4 aut | |
| 700 | 1 | |a Liu, Zhuang |0 (orcid)0000-0002-1629-1039 |4 aut | |
| 700 | 1 | |a Shi, Yifeng |4 aut | |
| 700 | 1 | |a Chen, Hao |4 aut | |
| 700 | 1 | |a Zhang, Wenzhao |4 aut | |
| 700 | 1 | |a Shi, Chaojie |4 aut | |
| 700 | 1 | |a Weng, Tianhao |4 aut | |
| 700 | 1 | |a Shi, Danrong |4 aut | |
| 700 | 1 | |a Zou, Shihui |0 (orcid)0000-0001-5564-4151 |4 aut | |
| 700 | 1 | |a Wang, Qi |0 (orcid)0000-0002-2246-1401 |4 aut | |
| 700 | 1 | |a Chen, Wei |0 (orcid)0000-0001-5366-7253 |4 aut | |
| 700 | 1 | |a Wu, Nanping |4 aut | |
| 700 | 1 | |a YAO, Hang-Ping |0 (orcid)0000-0001-6742-7074 |4 aut | |
| 700 | 1 | |a Xiao, Liping |4 aut | |
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