Seroepidemiologocal investigation on the infected genotype in Japanese encephalitis patients in coastal areas of China
Abstract Background Japanese encephalitis (JE) is a vaccine-preventable mosquito-borne disease caused by infection with the Japanese encephalitis virus (JEV). G1, G3 and G5 JEV have been isolated in China, but the dominant genotype circulating in Chinese coastal areas remains unknown. Besides, the emergence of G5 JEV infection case in South Korea suggests a risk of G5 JEV transmission in epidemic areas. We search for G5 JEV infected case and try to understand which genotype of JEV was more relative to human Japanese encephalitis in coastal provinces of China. Methods In this study, we collected serum specimens of JE cases in three coastal provinces of China (Guangdong, Zhejiang and Shandong Province) from 2018 to 2020 and conducted JEV cross-neutralization test against genotype 1, 3 and 5 JEV. In the same serum specimen, if one neutralization antibody titer had a 4-fold difference with the other two, the case was considered infected by that genotype of JEV. Results The acute serum specimens of clinical reported JE cases were obtained for laboratory confirming from hospitals in Shandong (92 cases), Zhejiang (192 cases) and Guangdong (77 cases) of China from 2018 to 2020. 70 of total 361 serum specimens were laboratory confirmed JEV infection. 2 cases were confirmed infected by genotype 1 JEV, 32 cases were by genotype 3 JEV and 2 was by genotype 5 JEV. Conclusions The investigation found that there were genotype 1, 3 and 5 JEV infections in JE cases in coastal area of China from 2018 to 2020. Genotype 3 was the main infection genotype among JE cases who have the definite infection genotype, and the infection case caused by genotype 5 JEV was confirmed serologically in China..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
ResearchSquare.com - (2023) vom: 09. Dez. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Weijia [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-3472430/v1 |
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| PPN (Katalog-ID): |
XRA041468422 |
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| 520 | |a Abstract Background Japanese encephalitis (JE) is a vaccine-preventable mosquito-borne disease caused by infection with the Japanese encephalitis virus (JEV). G1, G3 and G5 JEV have been isolated in China, but the dominant genotype circulating in Chinese coastal areas remains unknown. Besides, the emergence of G5 JEV infection case in South Korea suggests a risk of G5 JEV transmission in epidemic areas. We search for G5 JEV infected case and try to understand which genotype of JEV was more relative to human Japanese encephalitis in coastal provinces of China. Methods In this study, we collected serum specimens of JE cases in three coastal provinces of China (Guangdong, Zhejiang and Shandong Province) from 2018 to 2020 and conducted JEV cross-neutralization test against genotype 1, 3 and 5 JEV. In the same serum specimen, if one neutralization antibody titer had a 4-fold difference with the other two, the case was considered infected by that genotype of JEV. Results The acute serum specimens of clinical reported JE cases were obtained for laboratory confirming from hospitals in Shandong (92 cases), Zhejiang (192 cases) and Guangdong (77 cases) of China from 2018 to 2020. 70 of total 361 serum specimens were laboratory confirmed JEV infection. 2 cases were confirmed infected by genotype 1 JEV, 32 cases were by genotype 3 JEV and 2 was by genotype 5 JEV. Conclusions The investigation found that there were genotype 1, 3 and 5 JEV infections in JE cases in coastal area of China from 2018 to 2020. Genotype 3 was the main infection genotype among JE cases who have the definite infection genotype, and the infection case caused by genotype 5 JEV was confirmed serologically in China. | ||
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| 700 | 1 | |a Yin, Qikai |4 aut | |
| 700 | 1 | |a Liu, Shenghui |4 aut | |
| 700 | 1 | |a Wang, Ruichen |4 aut | |
| 700 | 1 | |a Fu, Shihong |4 aut | |
| 700 | 1 | |a Li, Fan |4 aut | |
| 700 | 1 | |a He, Ying |4 aut | |
| 700 | 1 | |a Nie, Kai |4 aut | |
| 700 | 1 | |a Liang, Guodong |4 aut | |
| 700 | 1 | |a Xu, Songtao |4 aut | |
| 700 | 1 | |a Yang, Guang |4 aut | |
| 700 | 1 | |a Wang, Huanyu |4 aut | |
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