Plasma p-tau231 increases at one-year intervals in cognitively unimpaired subjects
Abstract BACKGROUND: Plasma biomarkers indicative of Alzheimer's disease pathology constitute a non-invasive tool for diagnosing and classifying the disease. They are altered even in preclinical stages. Nonetheless, it is necessary to better understand their properties so they can be helpful in a clinical context. METHODS: We have evaluated plasma phosphorylated (p)-tau231 in a group of 146 cognitively unimpaired subjects in sequential visits and correlated their levels with different phenotypic traits. ATN status was defined based on CSF biomarkers. RESULTS: P-tau231 levels increase sequentially at intervals close to one year. This increase occurs even in A-T-N- subjects. Basal levels of p-tau231 correlate negatively with memory tests only in subjects with a sufficient amyloid load. CONCLUSIONS: P-tau231 is a sensitive marker for detecting early signs of neuronal network impairment by amyloid. Longer-term studies are needed to characterize better p-tau231 evolution and its relationship with the different phases of the disease..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
ResearchSquare.com - (2023) vom: 21. Nov. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Martínez-Dubarbie, Francisco [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-2995638/v1 |
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| PPN (Katalog-ID): |
XRA039769178 |
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| 520 | |a Abstract BACKGROUND: Plasma biomarkers indicative of Alzheimer's disease pathology constitute a non-invasive tool for diagnosing and classifying the disease. They are altered even in preclinical stages. Nonetheless, it is necessary to better understand their properties so they can be helpful in a clinical context. METHODS: We have evaluated plasma phosphorylated (p)-tau231 in a group of 146 cognitively unimpaired subjects in sequential visits and correlated their levels with different phenotypic traits. ATN status was defined based on CSF biomarkers. RESULTS: P-tau231 levels increase sequentially at intervals close to one year. This increase occurs even in A-T-N- subjects. Basal levels of p-tau231 correlate negatively with memory tests only in subjects with a sufficient amyloid load. CONCLUSIONS: P-tau231 is a sensitive marker for detecting early signs of neuronal network impairment by amyloid. Longer-term studies are needed to characterize better p-tau231 evolution and its relationship with the different phases of the disease. | ||
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| 700 | 1 | |a Lage-Martínez, Carmen |4 aut | |
| 700 | 1 | |a Molfetta, Guglielmo Di |4 aut | |
| 700 | 1 | |a Fernández-Matarrubia, Marta |4 aut | |
| 700 | 1 | |a Pozueta-Cantudo, Ana |4 aut | |
| 700 | 1 | |a García-Martínez, María |4 aut | |
| 700 | 1 | |a Corrales-Pardo, Andrea |4 aut | |
| 700 | 1 | |a Bravo, María |4 aut | |
| 700 | 1 | |a Jiménez-Bonilla, Julio |4 aut | |
| 700 | 1 | |a Quirce, Remedios |4 aut | |
| 700 | 1 | |a de Lucas, Enrique Marco |4 aut | |
| 700 | 1 | |a Drake-Pérez, Marta |4 aut | |
| 700 | 1 | |a López-Hoyos, Marcos |4 aut | |
| 700 | 1 | |a Irure-Ventura, Juan |4 aut | |
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| 700 | 1 | |a J.Ashton, Nicholas |4 aut | |
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| 700 | 1 | |a Rodríguez-Rodríguez, Eloy |4 aut | |
| 700 | 1 | |a Sánchez-Juan, Pascual |4 aut | |
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