Chimeric provirus of bovine leukemia virus/ SMAD family member 3 in cattle with enzootic bovine leukosis
Abstract Bovine leukemia virus (BLV) is a member of the family Retroviridae and causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from an EBL cow. The chimeric provirus harbored a SMAD3spliced sequence composed of exons 3–9 encoding the short isoform protein, and the BLV-SMAD3chimeric transcript was detectable in EBL cattle. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
ResearchSquare.com - (2024) vom: 19. Feb. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nao, Naganori [VerfasserIn] |
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| doi: |
10.21203/rs.3.rs-2632593/v1 |
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| PPN (Katalog-ID): |
XRA039766810 |
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| 245 | 1 | 0 | |a Chimeric provirus of bovine leukemia virus/ SMAD family member 3 in cattle with enzootic bovine leukosis |
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| 520 | |a Abstract Bovine leukemia virus (BLV) is a member of the family Retroviridae and causes enzootic bovine leukemia (EBL). However, the association between BLV infection and EBL development remains unclear. In this study, we identified a BLV/SMAD3chimeric provirus within CC2D2A intron 30 in monoclonal expanded malignant cells from an EBL cow. The chimeric provirus harbored a SMAD3spliced sequence composed of exons 3–9 encoding the short isoform protein, and the BLV-SMAD3chimeric transcript was detectable in EBL cattle. This is the first report of a BLV chimeric provirus that might be involved in EBL tumorigenesis. | ||
| 650 | 4 | |a Biology |7 (dpeaa)DE-84 | |
| 650 | 4 | |a 570 |7 (dpeaa)DE-84 | |
| 700 | 1 | |a Okagawa, Tomohiro |4 aut | |
| 700 | 1 | |a Nojiri, Naomi |4 aut | |
| 700 | 1 | |a Konnai, Satoru |4 aut | |
| 700 | 1 | |a Shimakura, Honami |4 aut | |
| 700 | 1 | |a Tominaga, Misono |4 aut | |
| 700 | 1 | |a Furihata, Hazuka Yoshida |4 aut | |
| 700 | 1 | |a Nishiyama, Eri |4 aut | |
| 700 | 1 | |a Matsudaira, Takahiro |4 aut | |
| 700 | 1 | |a Maekawa, Naoya |4 aut | |
| 700 | 1 | |a Murata, Shiro |4 aut | |
| 700 | 1 | |a Muramatsu, Masamichi |4 aut | |
| 700 | 1 | |a Ohashi, Kazuhiko |4 aut | |
| 700 | 1 | |a Saito, Masumichi |0 (orcid)0000-0001-7187-1186 |4 aut | |
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