Association of coronary plaque morphology with inflammatory biomarkers and target lesion revascularization in patients with chronic coronary syndrome: An optical coherence tomography study
Abstract Background: The characteristics of high-risk coronary atherosclerosis evaluated using optical coherence tomography can have a prognostic role. Inflammatory biomarkers may be related to the severity of coronary artery disease. This study investigated the association of high-risk morphological features of coronary plaques on optical coherence tomography with circulating levels of inflammatory biomarkers and adverse cardiovascular events. Methods: We prospectively analyzed the data of 30 consecutive patients with chronic coronary syndrome who underwent percutaneous coronary intervention using optical coherence tomography between April 2020 and November 2020 at our university hospital. Estimation of inflammatory biomarker levels and optical coherence tomography analysis focused on high-risk coronary plaque features were performed. Based on the coronary plaque risk score, patients were defined as having a low coronary plaque risk score (coronary plaque risk score≤3) or high coronary plaque risk score (coronary plaque risk score≥4). The primary outcome was target lesion revascularization. Results: Targetlesion revascularization was achieved in 6 (20%) patients within 15 months of percutaneous coronary intervention. High coronary plaque risk score on optical coherence tomography was directly correlated with target lesion revascularization (P=0.029). In logistic regression analysis, coronary plaque risk score was associated with target lesion revascularization (odds ratio, 10.0; 95% confidence interval, 1.34–74.5). Serum monocyte chemoattractant protein-1 level was significantly correlated with the coronary plaque risk score (P=0.020). Conclusions: In patients with chronic coronary syndrome, coronary plaque risk score may be a surrogate predictor of target lesion revascularization. Serum monocyte chemoattractant protein-1 may aid detection of high-risk coronary atherosclerosis..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
ResearchSquare.com - (2023) vom: 01. Aug. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Saiin, Kohei [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-2777474/v1 |
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| PPN (Katalog-ID): |
XRA039287173 |
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| 520 | |a Abstract Background: The characteristics of high-risk coronary atherosclerosis evaluated using optical coherence tomography can have a prognostic role. Inflammatory biomarkers may be related to the severity of coronary artery disease. This study investigated the association of high-risk morphological features of coronary plaques on optical coherence tomography with circulating levels of inflammatory biomarkers and adverse cardiovascular events. Methods: We prospectively analyzed the data of 30 consecutive patients with chronic coronary syndrome who underwent percutaneous coronary intervention using optical coherence tomography between April 2020 and November 2020 at our university hospital. Estimation of inflammatory biomarker levels and optical coherence tomography analysis focused on high-risk coronary plaque features were performed. Based on the coronary plaque risk score, patients were defined as having a low coronary plaque risk score (coronary plaque risk score≤3) or high coronary plaque risk score (coronary plaque risk score≥4). The primary outcome was target lesion revascularization. Results: Targetlesion revascularization was achieved in 6 (20%) patients within 15 months of percutaneous coronary intervention. High coronary plaque risk score on optical coherence tomography was directly correlated with target lesion revascularization (P=0.029). In logistic regression analysis, coronary plaque risk score was associated with target lesion revascularization (odds ratio, 10.0; 95% confidence interval, 1.34–74.5). Serum monocyte chemoattractant protein-1 level was significantly correlated with the coronary plaque risk score (P=0.020). Conclusions: In patients with chronic coronary syndrome, coronary plaque risk score may be a surrogate predictor of target lesion revascularization. Serum monocyte chemoattractant protein-1 may aid detection of high-risk coronary atherosclerosis. | ||
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| 700 | 1 | |a Kazui, Sho |4 aut | |
| 700 | 1 | |a Yasui, Yutaro |4 aut | |
| 700 | 1 | |a Takahashi, Yuki |4 aut | |
| 700 | 1 | |a Naito, Seiichiro |4 aut | |
| 700 | 1 | |a Takenaka, Sakae |4 aut | |
| 700 | 1 | |a Mizuguchi, Yoshifumi |4 aut | |
| 700 | 1 | |a Tada, Atsushi |4 aut | |
| 700 | 1 | |a Kobayashi, Yuta |4 aut | |
| 700 | 1 | |a Kato, Yoshiya |4 aut | |
| 700 | 1 | |a Omote, Kazunori |4 aut | |
| 700 | 1 | |a Sato, Takuma |4 aut | |
| 700 | 1 | |a Kamiya, Kiwamu |4 aut | |
| 700 | 1 | |a Nagai, Toshiyuki |4 aut | |
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| 700 | 1 | |a Anzai, Toshihisa |4 aut | |
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