Preoperative Supine Time for Adrenal Venous Sampling: A Prospective Randomized Controlled Trial
Abstract Background: Primary aldosteronism (PA) is the most common form of secondary hypertension, accounting for 5% of hypertensive patients and 17-23% in patients with resistant hypertension. Compared to the primary hypertension, PA is more prone to cause severe organ damage and even early death. Adrenal venous sampling (AVS) is an effective confirmatory test for subtyping unilateral and bilateral adrenal hyperplasia, helping physicians to make an accurate decision between surgery or medication to treat PA. Supine in bed before AVS is recommended for a desirable result of AVS according to guidelines. However, investigating study about the most optimal preoperative supine time before AVS is lacking. Methods/design: This is a single-center prospective randomized controlled study. 120 patients diagnosed as PA and with willing for further AVS examination will be included. Participants will be randomly allocated to 15-min supine time group or 2-hours supine time group. The primary outcome is the degree of biochemical remission (serum potassium and orthostatic ARR). The secondary outcomes are degree of the clinical remission (blood pressure, type and dose of antihypertensive drugs), the technical success rate and the adverse event of AVS (selective index≥2 is considered as successful surgery without corticotropin stimulate). Discussion: PA is an intractable public health problem, and many techniques including AVS have been developed to correctly identify this disease. This study will help to understand whether the length of preoperative supine time would affect the diagnostic efficacy of AVS, and thus help to formulate a more reasonable AVS procedure. Trial registration: ClinicalTrials.gov, ID: NCT05658705. Registered on 10 September 2022..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
ResearchSquare.com - (2024) vom: 08. Jan. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Liu, Zhenjie [VerfasserIn] |
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| doi: |
10.21203/rs.3.rs-2616450/v1 |
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| PPN (Katalog-ID): |
XRA039255328 |
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| 520 | |a Abstract Background: Primary aldosteronism (PA) is the most common form of secondary hypertension, accounting for 5% of hypertensive patients and 17-23% in patients with resistant hypertension. Compared to the primary hypertension, PA is more prone to cause severe organ damage and even early death. Adrenal venous sampling (AVS) is an effective confirmatory test for subtyping unilateral and bilateral adrenal hyperplasia, helping physicians to make an accurate decision between surgery or medication to treat PA. Supine in bed before AVS is recommended for a desirable result of AVS according to guidelines. However, investigating study about the most optimal preoperative supine time before AVS is lacking. Methods/design: This is a single-center prospective randomized controlled study. 120 patients diagnosed as PA and with willing for further AVS examination will be included. Participants will be randomly allocated to 15-min supine time group or 2-hours supine time group. The primary outcome is the degree of biochemical remission (serum potassium and orthostatic ARR). The secondary outcomes are degree of the clinical remission (blood pressure, type and dose of antihypertensive drugs), the technical success rate and the adverse event of AVS (selective index≥2 is considered as successful surgery without corticotropin stimulate). Discussion: PA is an intractable public health problem, and many techniques including AVS have been developed to correctly identify this disease. This study will help to understand whether the length of preoperative supine time would affect the diagnostic efficacy of AVS, and thus help to formulate a more reasonable AVS procedure. Trial registration: ClinicalTrials.gov, ID: NCT05658705. Registered on 10 September 2022. | ||
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