Adjuvant chemotherapy in T3 upper urinary tract urothelial carcinoma: retrospective cohort study
Abstract Background The benefit of adjuvant chemotherapy was investigated for patients with T3 upper urinary tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy. Methods This is a multicenter retrospective observational study of 482 patients with pathological T3 N0 and Nx UTUC who underwent radical nephroureterectomy with and without adjuvant chemotherapy. The median overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS) of patients who received adjuvant chemotherapy were analyzed to determine predictors of patient prognosis. Results Of the 482 patients, 140 (29.0%) received adjuvant chemotherapy. Adjuvant chemotherapy showed a benefit only for the median DFS rate (58% vs 49%; p = 0.04). Multivariate analyses revealed that adjuvant chemotherapy improved median DFS (HR 0.537; CI 0.35–0.83; p = 0.005). Surgical margin also significantly influenced median OS (HR 4.038; p < 0.001), CSS (HR 3.926; p < 0.001), and DFS (HR 3.201; p < 0.001). Conclusions Adjuvant chemotherapy improved DFS but did not improve OS or CSS in patients with pathological T3 N0 and Nx UTUC..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
ResearchSquare.com - (2023) vom: 20. Apr. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Chang, Yi-Huei [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-2667589/v1 |
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XRA039155358 |
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| 520 | |a Abstract Background The benefit of adjuvant chemotherapy was investigated for patients with T3 upper urinary tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy. Methods This is a multicenter retrospective observational study of 482 patients with pathological T3 N0 and Nx UTUC who underwent radical nephroureterectomy with and without adjuvant chemotherapy. The median overall survival (OS), cancer-specific survival (CSS), and disease-free survival (DFS) of patients who received adjuvant chemotherapy were analyzed to determine predictors of patient prognosis. Results Of the 482 patients, 140 (29.0%) received adjuvant chemotherapy. Adjuvant chemotherapy showed a benefit only for the median DFS rate (58% vs 49%; p = 0.04). Multivariate analyses revealed that adjuvant chemotherapy improved median DFS (HR 0.537; CI 0.35–0.83; p = 0.005). Surgical margin also significantly influenced median OS (HR 4.038; p < 0.001), CSS (HR 3.926; p < 0.001), and DFS (HR 3.201; p < 0.001). Conclusions Adjuvant chemotherapy improved DFS but did not improve OS or CSS in patients with pathological T3 N0 and Nx UTUC. | ||
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| 700 | 1 | |a Tai, Ta-Yao |4 aut | |
| 700 | 1 | |a Yeh, Hsin-Chih |4 aut | |
| 700 | 1 | |a Lee, Hsiang-Ying |4 aut | |
| 700 | 1 | |a Huang, Chao-Yuan |4 aut | |
| 700 | 1 | |a Chen, Chung-Hsin |4 aut | |
| 700 | 1 | |a Tsai, Yao-Chou |4 aut | |
| 700 | 1 | |a Yu, Chih-Chin |4 aut | |
| 700 | 1 | |a Tsai, Chung-You |4 aut | |
| 700 | 1 | |a Cheng, Pai-Yu |4 aut | |
| 700 | 1 | |a Hsueh, Thomas Y. |4 aut | |
| 700 | 1 | |a Chiu, Allen W. |4 aut | |
| 700 | 1 | |a Jiang, Yuan-Hong |4 aut | |
| 700 | 1 | |a Lee, Yu-Khun |4 aut | |
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| 700 | 1 | |a Huang, Hsu-Che |4 aut | |
| 700 | 1 | |a Chen, I-Hsuan Alan |4 aut | |
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| 700 | 1 | |a Lin, Wei Yu |4 aut | |
| 700 | 1 | |a Hu, Su-Wei |4 aut | |
| 700 | 1 | |a Fang, Jen-Kai |4 aut | |
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| 700 | 1 | |a Chung, Chi-Jung |4 aut | |
| 700 | 1 | |a Huang, Chi-Ping |4 aut | |
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