WITHDRAWN: Zn-MOF hydrogel: Regulation of ROS-mediated inflammatory microenvironment for treatment of atopic dermatitis
Abstract Atopic dermatitis (AD) is a chronic and recurrent inflammation disease associated with immune dysfunction. The high level of reactive oxygen species (ROS) causes high oxidative stress and further results in the deterioration of AD. Here, a Zn-MOF hydrogel is prepared to regulate ROS-mediated inflammatory microenvironment. The hydrogel with high ROS scavenging performance has a good protective effect on cells. The antibacterial agent Zn-MOF(ZIF-8) loaded into the hydrogel (GelZIF-8) can reduce its toxic and side effects and show a lasting and effective antibacterial activity. In the AD-induced mouse model, Gel@ZIF-8 can significantly enhance the therapeutic effect, such as reduce the thickness of epidermis, the number of mast cells and IgE antibodies. The results indicate that the ROS-scavenging hydrogel could treat the AD by regulating the inflammatory microenvironment, providing a promising treatment for managing AD..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
ResearchSquare.com - (2024) vom: 15. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Qiu, Lirong [VerfasserIn] |
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| doi: |
10.21203/rs.3.rs-2623820/v1 |
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| PPN (Katalog-ID): |
XRA038885581 |
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| 100 | 1 | |a Qiu, Lirong |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a WITHDRAWN: Zn-MOF hydrogel: Regulation of ROS-mediated inflammatory microenvironment for treatment of atopic dermatitis |
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| 520 | |a Abstract Atopic dermatitis (AD) is a chronic and recurrent inflammation disease associated with immune dysfunction. The high level of reactive oxygen species (ROS) causes high oxidative stress and further results in the deterioration of AD. Here, a Zn-MOF hydrogel is prepared to regulate ROS-mediated inflammatory microenvironment. The hydrogel with high ROS scavenging performance has a good protective effect on cells. The antibacterial agent Zn-MOF(ZIF-8) loaded into the hydrogel (GelZIF-8) can reduce its toxic and side effects and show a lasting and effective antibacterial activity. In the AD-induced mouse model, Gel@ZIF-8 can significantly enhance the therapeutic effect, such as reduce the thickness of epidermis, the number of mast cells and IgE antibodies. The results indicate that the ROS-scavenging hydrogel could treat the AD by regulating the inflammatory microenvironment, providing a promising treatment for managing AD. | ||
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| 700 | 1 | |a Ouyang, Chengcheng |4 aut | |
| 700 | 1 | |a Zhang, Wei |4 aut | |
| 700 | 1 | |a Liu, Jia |4 aut | |
| 700 | 1 | |a Yu, Luting |4 aut | |
| 700 | 1 | |a Chen, Guoguang |4 aut | |
| 700 | 1 | |a Ren, Lili |4 aut | |
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| 856 | 4 | 0 | |u http://dx.doi.org/10.21203/rs.3.rs-2623820/v1 |z kostenfrei |3 Volltext |
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