WITHDRAWN: Influence of a structured microbiological endotracheal monitoring on the outcome of critically ill COVID-19 patients: an observational study
Abstract Purpose In past influenza pandemics and the current COVID-19 pandemic, bacterial endotracheal superinfections are a well-known risk factor for higher morbidity and mortality. The goal of this study was to investigate the influence of a structured, objective, microbiological monitoring on the prognosis of COVID-19 patients with mechanical ventilation. Methods A structured microbiological monitoring (at intubation, then every 3 days) included collection of endotracheal material. Data analysis focused on the spectrum of bacterial pathogens, mortality, as well as ICU-, hospital-, and mechanical ventilation duration. Results 29% of the patients showed bacterial coinfection at the time of intubation or within 48h, 56% developed ventilator-associated pneumonia (VAP). Even though patients with VAP had significantly longer ICU-, hospital and mechanical ventilation duration, there was no significant difference in mortality between patients with ventilator-associated pneumonia and patients without bacterial infection. Conclusion Bacterial coinfections and ventilator-associated pneumonia are common complications in influenza and COVID-19 patients. In contrast to already published studies, in our study implementing a structured microbiological monitoring, COVID-19 patients with ventilator-associated pneumonia did not show higher mortality. Thus, a standardized, objective, microbiological screening can help detect coinfections and ventilator-associated infections, refining the anti-infective therapy and influencing the patient outcome positively..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
ResearchSquare.com - (2024) vom: 15. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dibos, Miriam [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-2436406/v1 |
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| 520 | |a Abstract Purpose In past influenza pandemics and the current COVID-19 pandemic, bacterial endotracheal superinfections are a well-known risk factor for higher morbidity and mortality. The goal of this study was to investigate the influence of a structured, objective, microbiological monitoring on the prognosis of COVID-19 patients with mechanical ventilation. Methods A structured microbiological monitoring (at intubation, then every 3 days) included collection of endotracheal material. Data analysis focused on the spectrum of bacterial pathogens, mortality, as well as ICU-, hospital-, and mechanical ventilation duration. Results 29% of the patients showed bacterial coinfection at the time of intubation or within 48h, 56% developed ventilator-associated pneumonia (VAP). Even though patients with VAP had significantly longer ICU-, hospital and mechanical ventilation duration, there was no significant difference in mortality between patients with ventilator-associated pneumonia and patients without bacterial infection. Conclusion Bacterial coinfections and ventilator-associated pneumonia are common complications in influenza and COVID-19 patients. In contrast to already published studies, in our study implementing a structured microbiological monitoring, COVID-19 patients with ventilator-associated pneumonia did not show higher mortality. Thus, a standardized, objective, microbiological screening can help detect coinfections and ventilator-associated infections, refining the anti-infective therapy and influencing the patient outcome positively. | ||
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