Recurrent Respiratory Papillomatosis (RRP) – Meta-analyses on the use of the HPV vaccine as adjuvant therapy.
Abstract Objectives and importance:Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vaccination alongside surgery were meta-analysed to test effect on burden of disease.MethodsDatabases accessed Nov & Dec 2021[PubMed, Cochrane, Embase & Web of Science]. Main outcome measured: Mean paired differences in the number of surgeries or recurrences per month. Analyses: Random effect maximal likelihood estimation model using the Stata module Mataan(StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX:StataCorp LLC.)Resultsn=38 patients, suitable for syntheses with one previous meta-analyses(4 published, 2 unpublished studies)n=63, total of n=101 patients. Overall mean reduction of ≥8 recurrences compared to similar pre-vaccination period (95% CI [3.84, 10.98]) over 5 years. ConclusionsMeta-analyses favours HPV vaccine as adjunct therapy alongside surgery Trial registration: PROSPERO (awaiting number).
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
ResearchSquare.com - (2022) vom: 08. Aug. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Goon, Peter [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-1744765/v1 |
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| 520 | |a Abstract Objectives and importance:Recurrent Respiratory Papillomatosis(RRP) is a rare disease with severe morbidity. Treatment is surgical. Prevailing viewpoint is that prophylactic HPV vaccines do not have therapeutic benefit due to their modus operandi. Studies on HPV vaccination alongside surgery were meta-analysed to test effect on burden of disease.MethodsDatabases accessed Nov & Dec 2021[PubMed, Cochrane, Embase & Web of Science]. Main outcome measured: Mean paired differences in the number of surgeries or recurrences per month. Analyses: Random effect maximal likelihood estimation model using the Stata module Mataan(StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX:StataCorp LLC.)Resultsn=38 patients, suitable for syntheses with one previous meta-analyses(4 published, 2 unpublished studies)n=63, total of n=101 patients. Overall mean reduction of ≥8 recurrences compared to similar pre-vaccination period (95% CI [3.84, 10.98]) over 5 years. ConclusionsMeta-analyses favours HPV vaccine as adjunct therapy alongside surgery Trial registration: PROSPERO (awaiting number) | ||
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