Survival of persons living with HIV/AIDS: A multicentric study from India
Abstract Persons living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLHA) enrolled from antiretroviral therapy (ART) centers located in three different cities in India – Delhi, Pune and Kolkata, and were followed up at six monthly intervals monitoring the WHO stage, CD4 counts, complete blood counts and liver and kidney function tests, for a duration of three years. The incidence of mortality among HIV/AIDS patients on ART was 5·0 per 1000 patient years (21/1410, 1.4%). Age at initiation of ART being above 35 years was the only significant predictor of mortality (log rank p = 0·018). Multivariable analysis showed significant association of an unfavourable outcome (defined as mortality or development of opportunistic infection during follow-up) with male gender (adjusted odds ratio (AOR) = 5.26, p = < 0.01) and being unmarried at ART initiation (AOR = 1.39, p = 0.005). The survival of PLHA with good adherence to ART is independent of the WHO stage or CD4 counts at initiation of ART..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
ResearchSquare.com - (2022) vom: 28. Juni Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sinha, Sanjeev [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-1470315/v1 |
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| 520 | |a Abstract Persons living with human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) (PLHA) enrolled from antiretroviral therapy (ART) centers located in three different cities in India – Delhi, Pune and Kolkata, and were followed up at six monthly intervals monitoring the WHO stage, CD4 counts, complete blood counts and liver and kidney function tests, for a duration of three years. The incidence of mortality among HIV/AIDS patients on ART was 5·0 per 1000 patient years (21/1410, 1.4%). Age at initiation of ART being above 35 years was the only significant predictor of mortality (log rank p = 0·018). Multivariable analysis showed significant association of an unfavourable outcome (defined as mortality or development of opportunistic infection during follow-up) with male gender (adjusted odds ratio (AOR) = 5.26, p = < 0.01) and being unmarried at ART initiation (AOR = 1.39, p = 0.005). The survival of PLHA with good adherence to ART is independent of the WHO stage or CD4 counts at initiation of ART. | ||
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