Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort
Abstract Background & Aims : The evidence of relationship between dietary intake of folate, vitamin B6 and vitamin B12 and cardiovascular diseases(CVD) in UK populations is limited. We aimed to analyze the association of dietary intake of folate, vitamin B6, and vitamin B12 with CVD events [stroke, myocardial infarction(MI)] and CVD mortality. Methods We included 115664 participants, aged 40–70 years, with no CVD events or cancer at baseline, enrolled between 2006 and 2010 and followed up to the end of 2018. Dietary intake was measured with an online 24-hour dietary assessment. Multivariable Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the associations. Results After multivariate adjustment, higher dietary folate intake was associated with a lower risk of CVD events [HR per standard deviation(SD) 0.95, 95% CI 0.93 to 0.98], stroke (HR per SD 0.95, 95% CI 0.91 to 0.99), MI(HR per SD 0.94, 95% CI 0.91 to 0.98),CVD mortality(HR per SD 0.90, 95% CI 0.83 to 0.97). Each tablespoons/day higher intake of raw vegetable intake, pieces/day higher intake of fresh fruit intake and bowls/week higher intake of cereal intake were associated with higher intakes of of folate every 0.02,0.06 and 0.05 SD, respectively. E-value analysis suggested robustness to unmeasured confounding. Conclusion Each increase in folate intakes was related to 5% lower risks of total CVD events and 10% lower risks of CVD mortality. Our findings support that strengthening dietary folate intake as a primary prevention strategy for CVD events and CVD mortality..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
ResearchSquare.com - (2023) vom: 04. Juli Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Bo-Ya [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-1473209/v1 |
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| PPN (Katalog-ID): |
XRA035585307 |
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| 245 | 1 | 0 | |a Associations of dietary folate, vitamin B6 and B12 intake with cardiovascular outcomes in 115664 participants: a large UK population-based cohort |
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| 520 | |a Abstract Background & Aims : The evidence of relationship between dietary intake of folate, vitamin B6 and vitamin B12 and cardiovascular diseases(CVD) in UK populations is limited. We aimed to analyze the association of dietary intake of folate, vitamin B6, and vitamin B12 with CVD events [stroke, myocardial infarction(MI)] and CVD mortality. Methods We included 115664 participants, aged 40–70 years, with no CVD events or cancer at baseline, enrolled between 2006 and 2010 and followed up to the end of 2018. Dietary intake was measured with an online 24-hour dietary assessment. Multivariable Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the associations. Results After multivariate adjustment, higher dietary folate intake was associated with a lower risk of CVD events [HR per standard deviation(SD) 0.95, 95% CI 0.93 to 0.98], stroke (HR per SD 0.95, 95% CI 0.91 to 0.99), MI(HR per SD 0.94, 95% CI 0.91 to 0.98),CVD mortality(HR per SD 0.90, 95% CI 0.83 to 0.97). Each tablespoons/day higher intake of raw vegetable intake, pieces/day higher intake of fresh fruit intake and bowls/week higher intake of cereal intake were associated with higher intakes of of folate every 0.02,0.06 and 0.05 SD, respectively. E-value analysis suggested robustness to unmeasured confounding. Conclusion Each increase in folate intakes was related to 5% lower risks of total CVD events and 10% lower risks of CVD mortality. Our findings support that strengthening dietary folate intake as a primary prevention strategy for CVD events and CVD mortality. | ||
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| 700 | 1 | |a Dong, Hao-Yu |4 aut | |
| 700 | 1 | |a Xu, Ying |4 aut | |
| 700 | 1 | |a Xu, Duo |4 aut | |
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| 700 | 1 | |a Han, Li-yuan |4 aut | |
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