Lung Ultrasound Score has Better Diagnostic Ability Than NT-PROBNP to Predict Moderate–Severe Bronchopulmonary Dysplasia
Abstract Purpose: N-terminal end of B-type natriuretic peptide (NT-proBNP) and lung ultrasound (LUS) score have been proven to be adequate early biomarkers of bronchopulmonary dysplasia (BPD) in preterm infants. Our aim was to study if the predictive capacity of each one is increased by analyzing them together.Methods: We included infants born before 32 weeks, with NT-proBNP and LUS score on the first day of life (DOL), 3rd, 7th and 14th DOL, and compare the diagnostic ability for moderate-severe BPD (msBPD) of each biomarker and in combination. We also compared them with a multivariate model of msBPD using only clinical variables.Results: The sample size was 133 patients, and twenty seven (20%) developed msBPD. LUS score on 7th DOL had better performance, compared to NT-proBNP at the same moment: area under the receiver operating characteristic curve (AUC) 0.83 (0.75-0.89) versus 0.66 (0.56-0.75), p=0.003, without differences in the rest of times studied. This values did not increase using the combination of both. A multivariate regression model that included birth weight and invasive mechanical ventilation (IMV) at 7th DOL predicted msBPD with the same AUC-ROC than NT-proBNP, LUS score or both. Neither the addition of any of these biomarkers, nor together, increase the diagnostic accuracy of the clinical model.Conclusion: LUS score is better predictor of msBPD on 7th DOL than NT-proBNP in preterm infants born before 32 weeks, although they have similar diagnostic accuracy on 14th DOL. Neither of them, nor together, have better AUC for msBPD than a clinical model with birthweight and the need of IMV at 7th DOL..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
ResearchSquare.com - (2022) vom: 21. Feb. Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Alonso-Ojembarrena, Almudena [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-1351029/v1 |
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| funding: |
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| PPN (Katalog-ID): |
XRA035292261 |
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| 245 | 1 | 0 | |a Lung Ultrasound Score has Better Diagnostic Ability Than NT-PROBNP to Predict Moderate–Severe Bronchopulmonary Dysplasia |
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| 520 | |a Abstract Purpose: N-terminal end of B-type natriuretic peptide (NT-proBNP) and lung ultrasound (LUS) score have been proven to be adequate early biomarkers of bronchopulmonary dysplasia (BPD) in preterm infants. Our aim was to study if the predictive capacity of each one is increased by analyzing them together.Methods: We included infants born before 32 weeks, with NT-proBNP and LUS score on the first day of life (DOL), 3rd, 7th and 14th DOL, and compare the diagnostic ability for moderate-severe BPD (msBPD) of each biomarker and in combination. We also compared them with a multivariate model of msBPD using only clinical variables.Results: The sample size was 133 patients, and twenty seven (20%) developed msBPD. LUS score on 7th DOL had better performance, compared to NT-proBNP at the same moment: area under the receiver operating characteristic curve (AUC) 0.83 (0.75-0.89) versus 0.66 (0.56-0.75), p=0.003, without differences in the rest of times studied. This values did not increase using the combination of both. A multivariate regression model that included birth weight and invasive mechanical ventilation (IMV) at 7th DOL predicted msBPD with the same AUC-ROC than NT-proBNP, LUS score or both. Neither the addition of any of these biomarkers, nor together, increase the diagnostic accuracy of the clinical model.Conclusion: LUS score is better predictor of msBPD on 7th DOL than NT-proBNP in preterm infants born before 32 weeks, although they have similar diagnostic accuracy on 14th DOL. Neither of them, nor together, have better AUC for msBPD than a clinical model with birthweight and the need of IMV at 7th DOL. | ||
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| 700 | 1 | |a Alonso-Quintela, Paula |e verfasserin |4 aut | |
| 700 | 1 | |a Zafra-Rodriguez, Pamela |e verfasserin |4 aut | |
| 700 | 1 | |a Oulego-Erroz, Ignacio |e verfasserin |4 aut | |
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