Changes of cardiac magnetic resonance T1 and ECV values in healthy adults of different sex and age
Abstract [Background] The correlation between T1 and ECV value and myocardial fibrosis has been confirmed, and many disease may change T1 and ECV value. The purpose of this reseach is to clarify the T1 mapping and extracellular volume (ECV) value of healthy adults in 3 Tesla (T) magnetic resonance imaging (MRI), and to study the relationship between the values with age and sex.[Methods] We recruited 87 healthy adult subjects (mean age 38 ± 11 years; 61% were females) for cardiac magnetic resonance examination at 3T MRI. The left ventricular function parameters were obtained from functional imaging. T1 mapping was performed using an improved Look-Locker reversal recovery sequence after motion correction. [Results] Under 3T field strength, T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 value and ECV values of female myocardium were higher than those of males (1,274 ± 56 vs. 1,241 ± 40, P = 0.003; 29.6% ± 2.6% vs. 26.2% ± 2.1%, P < 0.001). Only sex (Beta = 0.311, P = 0.003) was independently related to the native T1 mapping of left ventricular myocardium, while sex (Beta = 0.572, P < 0.001) and age (Beta = 0.501, P = 0.003) were related to the ECV value of left ventricular myocardium. T1 value (P = 0.002) and ECV value (P = 0.013) increased significantly from the base to the apex. There were significant differences in the T1 and ECV value between each segment (P < 0.001) in the base of the left ventricle. [Conclusions] T1 and ECV values of females were significantly higher than those of males. The ECV values of males increased with age, while T1 value in males and T1 and ECV values in females had no significant relationship with age..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
ResearchSquare.com - (2022) vom: 03. März Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Huang, Shumei [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-1249581/v1 |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
XRA035280786 |
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| 245 | 1 | 0 | |a Changes of cardiac magnetic resonance T1 and ECV values in healthy adults of different sex and age |
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| 520 | |a Abstract [Background] The correlation between T1 and ECV value and myocardial fibrosis has been confirmed, and many disease may change T1 and ECV value. The purpose of this reseach is to clarify the T1 mapping and extracellular volume (ECV) value of healthy adults in 3 Tesla (T) magnetic resonance imaging (MRI), and to study the relationship between the values with age and sex.[Methods] We recruited 87 healthy adult subjects (mean age 38 ± 11 years; 61% were females) for cardiac magnetic resonance examination at 3T MRI. The left ventricular function parameters were obtained from functional imaging. T1 mapping was performed using an improved Look-Locker reversal recovery sequence after motion correction. [Results] Under 3T field strength, T1 value of the myocardium of healthy adults was 1,261 ± 52, and the ECV value was 28.3% ± 2.9%. T1 value and ECV values of female myocardium were higher than those of males (1,274 ± 56 vs. 1,241 ± 40, P = 0.003; 29.6% ± 2.6% vs. 26.2% ± 2.1%, P < 0.001). Only sex (Beta = 0.311, P = 0.003) was independently related to the native T1 mapping of left ventricular myocardium, while sex (Beta = 0.572, P < 0.001) and age (Beta = 0.501, P = 0.003) were related to the ECV value of left ventricular myocardium. T1 value (P = 0.002) and ECV value (P = 0.013) increased significantly from the base to the apex. There were significant differences in the T1 and ECV value between each segment (P < 0.001) in the base of the left ventricle. [Conclusions] T1 and ECV values of females were significantly higher than those of males. The ECV values of males increased with age, while T1 value in males and T1 and ECV values in females had no significant relationship with age. | ||
| 700 | 1 | |a Zhang, Meng |e verfasserin |4 aut | |
| 700 | 1 | |a Yu, Kanghui |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Chunlong |e verfasserin |4 aut | |
| 700 | 1 | |a Lan, Zhihong |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Shiqi |e verfasserin |4 aut | |
| 700 | 1 | |a Ma, Xiaofen |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Yunfan |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Guihua |e verfasserin |4 aut | |
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