Gut Microbiota Profiles of Systemic Lupus Erythematosus Patients with Anxiety or Depression

Abstract Background Patients with systemic lupus erythematosus (SLE) often experience anxiety and depression. Recent studies have shown involvement of intestinal dysbiosis in SLE and also psychosomatic disorders. However, there are no reports on the gut microbiota profile of patient with both conditions: SLE and anxiety or depression. We aimed to study gut microbiota profiles among SLE patients with gastrointestinal symptoms and anxiety or depression by sequencing V3–V4 region of the 16S rRNA gene from the stool samples. Results Of the 41 SLE patients who participated in the study, 53.66% had anxiety and 14.63% had depression. We found a higher proportion of Bacteroidetes and lower diversity indices in patients with anxiety than in those without anxiety. We also found a higher proportion of Bacteroidetes and lower Firmicutes/Bacteroidetes ratios and diversity indices in patients with depression than in those without depression. Moreover, compared to other groups, patients with symptoms of both anxiety and depression had the highest proportion of Bacteroidetes and lowest proportion of Firmicutes, Firmicutes/Bacteroidetes ratios, and diversity indices. Further analysis showed that there was a significant correlation between the proportion of Bacteroides and the anxiety score (r = 0.349; p = 0.03) as well as with lupus activity (r = 0.36; p = 0.02). There was also significant correlation between diversity indices and lupus activity (r= -0.34; p = 0.03 for Chao1 index, r= -0.38; p = 0.01 for Shannon index, and r= -0.33; p = 0.03 for richness index). Conclusions SLE patients with both anxiety and depression showed more unfavorable gut dysbiosis parameter compared to SLE patients with only anxiety or depression and SLE patients without anxiety or depression. There was positive correlation between proportion of Bacteroides and lupus disease activity and negative correlation between diversity indices and lupus disease activity..

Medienart:	Preprint

Erscheinungsjahr:	2021
Erschienen:	2021

Enthalten in:	ResearchSquare.com - (2021) vom: 21. Sept. Zur Gesamtaufnahme - year:2021

Sprache:	Englisch

Beteiligte Personen:	widhani, alvina [VerfasserIn] Gebrina, Meutia [VerfasserIn] Putranto, Rudi [VerfasserIn] Abdullah, Murdani [VerfasserIn] Rinaldi, Ikhwan [VerfasserIn] Djauzi, Samsuridjal [VerfasserIn] Suyatna, Fransiscus D. [VerfasserIn] Dewi, Beti Ernawati [VerfasserIn] Yasmon, Andi [VerfasserIn] Rahayu, Susan [VerfasserIn]

Links:	Volltext [kostenfrei]

doi:	10.21203/rs.3.rs-885639/v1

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PPN (Katalog-ID):	XRA034753915