Successful use of anakinra in a patient with COVID-19- associated pericarditis
Abstract Since its recognition in December 2019 as a cause of pneumonia, SARS-CoV-2 infection has rapidly spread globally, causing a pandemic. Although it is an infectious disease, several distinct manifestations have been described in the setting of COVID-19, which result from the immune perturbations caused by this new Coronavirus. The heart is frequently involved in COVID-19 and is associated with severe outcomes. Pericarditis is rarely reported in COVID-19 patients and no reports on its treatment and outcome are available so far. Herein, we present a 33-year-old man with COVID-19-related pericarditis (COVID-19-RP) who was unresponsive to colchicine and nonsteroidal anti-inflammatory drugs, but was successfully treated with the IL-1R antagonist anakinra..
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Preprint| Erscheinungsjahr: |
2020 |
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| Erschienen: |
2020 |
| Enthalten in: |
ResearchSquare.com - (2020) vom: 18. Juni Zur Gesamtaufnahme - year:2020 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Karadeniz, Hazan [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-35779/v1 |
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| 520 | |a Abstract Since its recognition in December 2019 as a cause of pneumonia, SARS-CoV-2 infection has rapidly spread globally, causing a pandemic. Although it is an infectious disease, several distinct manifestations have been described in the setting of COVID-19, which result from the immune perturbations caused by this new Coronavirus. The heart is frequently involved in COVID-19 and is associated with severe outcomes. Pericarditis is rarely reported in COVID-19 patients and no reports on its treatment and outcome are available so far. Herein, we present a 33-year-old man with COVID-19-related pericarditis (COVID-19-RP) who was unresponsive to colchicine and nonsteroidal anti-inflammatory drugs, but was successfully treated with the IL-1R antagonist anakinra. | ||
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