The correlation Between Viral Clearance and Biochemical Outcomes of 94 Discharged Patients with COVID-19 Infection
Abstract Objective This study aims to evaluate the relationships between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People’s Hospital, enrolled from Jan 5 to Feb 13, 2020.Methods The clinical, and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical symptoms and signs, medical treatment, virus clearance and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein (CRP) were collected.Results COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir+ ribavirin.Conclusions Therapeutic regimen of IFN-α+lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin regimens might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection..
| Medienart: |
|
|---|
Preprint| Erscheinungsjahr: |
2020 |
|---|---|
| Erschienen: |
2020 |
| Enthalten in: |
ResearchSquare.com - (2020) vom: 03. Sept. Zur Gesamtaufnahme - year:2020 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Yuan, Jing [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| doi: |
10.21203/rs.3.rs-16554/v1 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
XRA034466657 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | XRA034466657 | ||
| 003 | DE-627 | ||
| 005 | 20230429191956.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220113s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.21203/rs.3.rs-16554/v1 |2 doi | |
| 035 | |a (DE-627)XRA034466657 | ||
| 035 | |a (ResearchSquare)10.21203/rs.3.rs-16554/v1 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 082 | 0 | |a 570 |q DE-84 | |
| 100 | 1 | |a Yuan, Jing |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a The correlation Between Viral Clearance and Biochemical Outcomes of 94 Discharged Patients with COVID-19 Infection |
| 264 | 1 | |c 2020 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract Objective This study aims to evaluate the relationships between viral clearance and blood biochemical index of 94 discharged patients with COVID-19 infection in Shenzhen Third People’s Hospital, enrolled from Jan 5 to Feb 13, 2020.Methods The clinical, and laboratory findings were extracted from the electronic medical records of the patients. The data were analysed and reviewed by a trained team of physicians. Information on clinical symptoms and signs, medical treatment, virus clearance and laboratory parameters including interleukin 6 (IL-6) and C-reactive protein (CRP) were collected.Results COVID-19 mRNA clearance ratio was identified significantly correlated with the decline of serum creatine kinase (CK) and lactate dehydrogenase (LDH) levels. Furthermore, COVID-19 mRNA clearance time was positively correlated with the length of hospital stay in patients treated with either IFN-α + lopinavir/ritonavir or IFN-α + lopinavir/ritonavir+ ribavirin.Conclusions Therapeutic regimen of IFN-α+lopinavir/ritonavir and IFN-α + lopinavir/ritonavir + ribavirin regimens might be beneficial for treatment of COVID-19. Serum LDH or CK decline may predict a favorable response to treatment of COVID-19 infection. | ||
| 700 | 1 | |a Zou, Rongrong |e verfasserin |4 aut | |
| 700 | 1 | |a Zeng, Lijiao |e verfasserin |4 aut | |
| 700 | 1 | |a Kou, Shanglong |e verfasserin |4 aut | |
| 700 | 1 | |a Lan, Jianfeng |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiaohe |e verfasserin |4 aut | |
| 700 | 1 | |a Liang, Yanhua |e verfasserin |4 aut | |
| 700 | 1 | |a Din, Xiaoyan |e verfasserin |4 aut | |
| 700 | 1 | |a Tan, Guoyu |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Shenghong |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yingxia |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Yanchao |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Zhaoqin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t ResearchSquare.com |g (2020) vom: 03. Sept. |
| 773 | 1 | 8 | |g year:2020 |g day:03 |g month:09 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.21203/rs.3.rs-16554/v1 |z kostenfrei |3 Volltext |
| 912 | |a GBV_XRA | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |j 2020 |b 03 |c 09 | ||
| 953 | |2 045F |a 570 | ||