COVID-19 Causes Changes in Photoplethysmography
Abstract Photoplethysmography (PPG) is the science behind many commonly used medical devices such as the pulse oximeter. PPG dropouts have been described in existing in vitro studies following artificially induced clot activation. Because COVID-19 causes increased arterial, venous and microvascular clot formation, our hypothesis is that PPG dropout identified in vitro can also be found in vivo in patients with COVID-19. To test this hypothesis, we prospectively collected PPG recordings and d-dimer levels for 197 ICU patients with COVID-19 and compared them with the PPG tracings from 300 non-COVID controls.Results demonstrated significant differences in rates of PPG dropout between patients with COVID-19 vs non-COVID controls. The median PPG dropout rate was 0.58 for COVID-19 patients (median 0.58, IQR 0.42-0.72, p<0.05) as opposed to a median 0.0 for non-COVID patients (median 0.0, IQR 0.0-0.0, p<0.05). Further, at least one incidence of PPG dropout was detected in 100% of COVID-19 patients, as opposed to 2.3% of non-COVID controls (p<0.05).PPG dropout also correlated closely with normalized serum d-dimer levels taken on the same day. D-dimer is an established biomarker used for COVID-19 disease severity and prognosis. The change in normalized d-dimer was plotted against the change in PPG dropout and a line of best fit was created. Linear regression resulted in R2 = 0.919 (p < 0.05), indicating that PPG dropout rate correlates with hemorheological changes in COVID-19 patients.The difference in the median and IQR PPG dropout values for patients with vs. without COVID-19 and the strong correlation with serum d-dimer shows the potential utility of such a metric for identifying individuals with acute hemorheological abnormalities associated with COVID-19..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
ResearchSquare.com - (2022) vom: 06. Juni Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Peck, Jacquelin [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-899550/v1 |
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| 520 | |a Abstract Photoplethysmography (PPG) is the science behind many commonly used medical devices such as the pulse oximeter. PPG dropouts have been described in existing in vitro studies following artificially induced clot activation. Because COVID-19 causes increased arterial, venous and microvascular clot formation, our hypothesis is that PPG dropout identified in vitro can also be found in vivo in patients with COVID-19. To test this hypothesis, we prospectively collected PPG recordings and d-dimer levels for 197 ICU patients with COVID-19 and compared them with the PPG tracings from 300 non-COVID controls.Results demonstrated significant differences in rates of PPG dropout between patients with COVID-19 vs non-COVID controls. The median PPG dropout rate was 0.58 for COVID-19 patients (median 0.58, IQR 0.42-0.72, p<0.05) as opposed to a median 0.0 for non-COVID patients (median 0.0, IQR 0.0-0.0, p<0.05). Further, at least one incidence of PPG dropout was detected in 100% of COVID-19 patients, as opposed to 2.3% of non-COVID controls (p<0.05).PPG dropout also correlated closely with normalized serum d-dimer levels taken on the same day. D-dimer is an established biomarker used for COVID-19 disease severity and prognosis. The change in normalized d-dimer was plotted against the change in PPG dropout and a line of best fit was created. Linear regression resulted in R2 = 0.919 (p < 0.05), indicating that PPG dropout rate correlates with hemorheological changes in COVID-19 patients.The difference in the median and IQR PPG dropout values for patients with vs. without COVID-19 and the strong correlation with serum d-dimer shows the potential utility of such a metric for identifying individuals with acute hemorheological abnormalities associated with COVID-19. | ||
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