The dynamic antibody responses on COVID-19 patients with different severity: A retrospective research

Abstract ObjectivesWe aimed to explore the association between dynamic antibody responses and the clinical severity of COVID-19. MethodsWe collected complete follow-up data of 777 pathogen-confirmed COVID-19 patients with corresponding IgG/IgM testing results. ResultsWe found the overall positive rates of IgG and IgM in severe patients were slightly higher than those in non-severe patients. In addition, higher IgG levels were detected in severe patients compared with non-severe patients (P=0.026). Through further analysis, our results showed that the statistical difference in the IgG only significant in serum samples taken ≤14 days from disease onset (P<0.001). In 74 patients who taken detection more than three times, by analyzing the antibody expression levels at different time points, we found that the difference between IgG was more obvious than that of IgM among severe/non-severe patients. In multivariate logistic regression models, after adjusting for cofactors, the higher anti-SARS-CoV-2 IgG level before 14 days from disease onset was independently associated with severe disease in COVID-19 (OR=1.310, 95%CI= 1.137-1.509).ConclusionWe observed differences in antibody responses among COVID-19 patients with different disease severity. A high IgG level in the first 14 days from disease onset might positively associate with severe disease..

Medienart:	Preprint

Erscheinungsjahr:	2020
Erschienen:	2020

Enthalten in:	ResearchSquare.com - (2020) vom: 18. Sept. Zur Gesamtaufnahme - year:2020

Sprache:	Englisch

Beteiligte Personen:	Lu, Wanrong [VerfasserIn] Wu, Ping [VerfasserIn] He, Liang [VerfasserIn] Meng, Yifan [VerfasserIn] Wu, Peng [VerfasserIn] Ding, Wencheng [VerfasserIn] Liu, Jia [VerfasserIn]

Links:	Volltext [kostenfrei]

doi:	10.21203/rs.3.rs-60563/v1

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PPN (Katalog-ID):	XRA034372210