Are Patients with Elevated Inflammatory Indications are at Higher Risk for Developing the Severe form of COVID-19?
Abstract BackgroundSince December 2019, when SARS-CoV-2 emerged with a cluster of unknown pneumonia cases in Wuhan city and rapidly spread throughout in worldwide and Iran, data have been needed on the clinical and diagnostic features of the affected Iranian patients.MethodsWe extracted data regarding 233 patients with laboratory-confirmed COVID-19 from Buali Hospital in Iran; clinical/praclinical and inflammatory indexes data were collected and analyzed. The data of laboratory examinations and chest CT findings were compared between death and non-severe patients.ResultsThe mean age of the patients was 49 years, (63%) of the patients were male. The acute respiratory distress syndrome occurred in 64 patients, including 53 who were admitted to the ICU and underwent invasive mechanical ventilation, and 28 who died. On the admission in death group, lymphopenia (79%), neutrophilia (79%), and thrombocytopenia (21%) were usually observed. Most patients had a high SII index of > 500 (68%), increased CRP level (88%). A high level of inflammatory index’s such as NLR, PLR and SII in death comparison with moderate groups were observed (P < 0.001). The most common symptoms were fever (70%) and cough (63%) on admission. Headache was uncommon (11%). On admission, ground-glass opacity with consolidation (mixed) was the most common radiologic finding on chest CT (51%). No radiographic or CT abnormality was found in 15 of 204 patients (7%). In ConclusionThese patients often presented without fever, and some did not have abnormal radiologic findings. Elevated NLR, PLR and SII can be considered as prognostic and risk stratifying factor of severe form of disease..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
ResearchSquare.com - (2022) vom: 28. Juli Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Rokni, Mohsen [VerfasserIn] |
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| doi: |
10.21203/rs.3.rs-34994/v1 |
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| PPN (Katalog-ID): |
XRA03387414X |
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| 520 | |a Abstract BackgroundSince December 2019, when SARS-CoV-2 emerged with a cluster of unknown pneumonia cases in Wuhan city and rapidly spread throughout in worldwide and Iran, data have been needed on the clinical and diagnostic features of the affected Iranian patients.MethodsWe extracted data regarding 233 patients with laboratory-confirmed COVID-19 from Buali Hospital in Iran; clinical/praclinical and inflammatory indexes data were collected and analyzed. The data of laboratory examinations and chest CT findings were compared between death and non-severe patients.ResultsThe mean age of the patients was 49 years, (63%) of the patients were male. The acute respiratory distress syndrome occurred in 64 patients, including 53 who were admitted to the ICU and underwent invasive mechanical ventilation, and 28 who died. On the admission in death group, lymphopenia (79%), neutrophilia (79%), and thrombocytopenia (21%) were usually observed. Most patients had a high SII index of > 500 (68%), increased CRP level (88%). A high level of inflammatory index’s such as NLR, PLR and SII in death comparison with moderate groups were observed (P < 0.001). The most common symptoms were fever (70%) and cough (63%) on admission. Headache was uncommon (11%). On admission, ground-glass opacity with consolidation (mixed) was the most common radiologic finding on chest CT (51%). No radiographic or CT abnormality was found in 15 of 204 patients (7%). In ConclusionThese patients often presented without fever, and some did not have abnormal radiologic findings. Elevated NLR, PLR and SII can be considered as prognostic and risk stratifying factor of severe form of disease. | ||
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