Etiology, clinical characteristics and coinfection status of bronchiolitis in Suzhou
Abstract Background: Bronchiolitis is a clinical syndrome commonly encountered in practice, particularly among infants and young children. To investigate the prevalence of pathogens in hospitalized children with bronchiolitis and study the clinical characteristics of bronchiolitis with or without coinfections. Methods: We investigated the respiratory specimens and clinical data of 1012 children with bronchiolitis who were treated at the Children’s Hospital of Soochow University between November 2011 and December 2018. The nasopharyngeal aspirates were examined to detect viruses by direct immunofluorescence assay or polymerase chain reaction (PCR). Mycoplasma pneumoniae (MP) was tested by PCR and enzyme-linked immunosorbent assay.Results: Of the 1012 children less than 2 years with bronchiolitis, causative pathogen was detected in 83.4% (842 of 1012). The majority of these (614 [72.9%] of 842) were single virus infection. The most common pathogens detected were respiratory syncytial virus (RSV) (44.4%), MP (15.6%), and human rhinovirus (HRV) (14.4%). Coinfection was identified in 13.5% (137 of 1012) of the patients. Coinfection includes virus mixed virus infection and virus mixed MP infection. Children with single virus infection had a higher rate of oxygen therapy compared with single MP infection. Conclusions: The most common pathogen detected in children with bronchiolitis is RSV, followed by MP and HRV. The high mix infection burden in bronchiolitis underscores a need for the sensitive and rapid diagnostics to accurately identify pathogens..
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Preprint| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
ResearchSquare.com - (2022) vom: 29. Juli Zur Gesamtaufnahme - year:2022 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tan, Jiahong [VerfasserIn] |
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| doi: |
10.21203/rs.2.21001/v4 |
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| PPN (Katalog-ID): |
XRA033567255 |
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| 245 | 1 | 0 | |a Etiology, clinical characteristics and coinfection status of bronchiolitis in Suzhou |
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| 520 | |a Abstract Background: Bronchiolitis is a clinical syndrome commonly encountered in practice, particularly among infants and young children. To investigate the prevalence of pathogens in hospitalized children with bronchiolitis and study the clinical characteristics of bronchiolitis with or without coinfections. Methods: We investigated the respiratory specimens and clinical data of 1012 children with bronchiolitis who were treated at the Children’s Hospital of Soochow University between November 2011 and December 2018. The nasopharyngeal aspirates were examined to detect viruses by direct immunofluorescence assay or polymerase chain reaction (PCR). Mycoplasma pneumoniae (MP) was tested by PCR and enzyme-linked immunosorbent assay.Results: Of the 1012 children less than 2 years with bronchiolitis, causative pathogen was detected in 83.4% (842 of 1012). The majority of these (614 [72.9%] of 842) were single virus infection. The most common pathogens detected were respiratory syncytial virus (RSV) (44.4%), MP (15.6%), and human rhinovirus (HRV) (14.4%). Coinfection was identified in 13.5% (137 of 1012) of the patients. Coinfection includes virus mixed virus infection and virus mixed MP infection. Children with single virus infection had a higher rate of oxygen therapy compared with single MP infection. Conclusions: The most common pathogen detected in children with bronchiolitis is RSV, followed by MP and HRV. The high mix infection burden in bronchiolitis underscores a need for the sensitive and rapid diagnostics to accurately identify pathogens. | ||
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| 700 | 1 | |a Jiang, Wujun |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Li |e verfasserin |4 aut | |
| 700 | 1 | |a Ji, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Yan, Yongdong |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Meiuan |e verfasserin |4 aut | |
| 700 | 1 | |a Shao, Xuejun |e verfasserin |4 aut | |
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