Waning of IgG, total and neutralizing antibodies 6 months post-vaccination with BNT162b2 in healthcare workers
Abstract Data about the duration of humoral response following COVID-19 vaccines are mandatory to establish appropriate population vaccination strategy. This study reports on the antibody decline observed in a population of COVID-19 naïve and COVID-19 positive individuals having received the two dose regimen of the BNT162b2 vaccine. Six months after vaccination, a significant antibody decline was observed in both COVID-19 naïve and positive individuals. The estimated half-life of total and IgG antibodies differs and ranges from several months for total antibodies to only several weeks for IgG antibodies, explaining the significant proportions of participants with non-detectable levels of neutralizing antibodies at 6 months. Whether this decrease correlates with an equivalent drop in the clinical effectiveness against the virus will require appropriate clinical studies. Nevertheless, these data are already important to support the decision-making on the potential use of a booster dose..
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Preprint| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
ResearchSquare.com - (2021) vom: 03. Sept. Zur Gesamtaufnahme - year:2021 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Bayart, Jean-Louis [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.21203/rs.3.rs-862966/v1 |
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| PPN (Katalog-ID): |
XRA033444773 |
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| 245 | 1 | 0 | |a Waning of IgG, total and neutralizing antibodies 6 months post-vaccination with BNT162b2 in healthcare workers |
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| 520 | |a Abstract Data about the duration of humoral response following COVID-19 vaccines are mandatory to establish appropriate population vaccination strategy. This study reports on the antibody decline observed in a population of COVID-19 naïve and COVID-19 positive individuals having received the two dose regimen of the BNT162b2 vaccine. Six months after vaccination, a significant antibody decline was observed in both COVID-19 naïve and positive individuals. The estimated half-life of total and IgG antibodies differs and ranges from several months for total antibodies to only several weeks for IgG antibodies, explaining the significant proportions of participants with non-detectable levels of neutralizing antibodies at 6 months. Whether this decrease correlates with an equivalent drop in the clinical effectiveness against the virus will require appropriate clinical studies. Nevertheless, these data are already important to support the decision-making on the potential use of a booster dose. | ||
| 700 | 1 | |a Douxfils, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Gillot, Constant |e verfasserin |4 aut | |
| 700 | 1 | |a David, Clara |e verfasserin |4 aut | |
| 700 | 1 | |a Mullier, François |e verfasserin |4 aut | |
| 700 | 1 | |a Elsen, Marc |e verfasserin |4 aut | |
| 700 | 1 | |a Eucher, Christine |e verfasserin |4 aut | |
| 700 | 1 | |a Eeckhoudt, Sandrine Van |e verfasserin |4 aut | |
| 700 | 1 | |a Roy, Tatiana |e verfasserin |4 aut | |
| 700 | 1 | |a Gerin, Vincent |e verfasserin |4 aut | |
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| 700 | 1 | |a Laurent, Christine |e verfasserin |4 aut | |
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