Divergent Synthesis of 17-nor-Cephalotane Diterpenoids through Developed Ynol-diene Cyclization
The diversity of complex molecular structures of Cephalotaxus diterpenoids poses great challenges in uncovering the pharmaceutical potential of these natural products. As a subfamily of Cephalotaxus diterpenoids, 17-nor-cephalotane diterpenoids possess polycyclic frameworks with seven-membered A ring bearing different oxidation states. On the basis of a novel ynol-diene cyclization developed as a rapid access to tropone unit, a concise and divergent strategy to 17-nor-cephalotane diterpenoids has been successfully established. Combining with a bioinspired stereoselective dual hydrogenation, the enantioselective total synthesis of (+)-3-deoxyfortalpinoid F, (+)-harringtonolide, (−)-fortalpinoids M/N/P, and analog (−)-20-deoxycephinoid P have been achieved in 14-17 linear longest steps starting from commercially available materials..
Medienart: |
Preprint |
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Erscheinungsjahr: |
2024 |
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Erschienen: |
2024 |
Enthalten in: |
chemRxiv.org - (2024) vom: 12. Apr. Zur Gesamtaufnahme - year:2024 |
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Sprache: |
Englisch |
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Beteiligte Personen: |
Sun, Zezhong [VerfasserIn] |
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Links: |
Volltext [kostenfrei] |
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Themen: |
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doi: |
10.26434/chemrxiv-2024-85cxs |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
XCH043251668 |
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