Putting MicroED to the Test: An Account of the Evaluation of 30 Diverse Pharmaceutical Compounds
The application of microcrystal electron diffraction (microED) to a variety of pharmaceutical compounds is reported. The examples and work detailed showcase the utility of microED as a routine technique for the rapid collection, analysis, and generation of structural data on a number of pharmaceutically relevant compounds, requiring minimal sample preparation and often without the need for time-consuming vitrification and cryo transfer processes. The development of a scripted data processing workflow allowed for simultaneous collection and processing of electron diffraction data, further expediting structural analysis of fifteen compounds..
| Medienart: |
|
|---|
Preprint| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
chemRxiv.org - (2022) vom: 01. Feb. Zur Gesamtaufnahme - year:2022 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Burch, Jessica E. [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.33774/chemrxiv-2021-h3tqz |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
XCH032803338 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | XCH032803338 | ||
| 003 | DE-627 | ||
| 005 | 20230429142733.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 211016s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.33774/chemrxiv-2021-h3tqz |2 doi | |
| 035 | |a (DE-627)XCH032803338 | ||
| 035 | |a (chemrXiv)10.33774/chemrxiv-2021-h3tqz | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Burch, Jessica E. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Putting MicroED to the Test: An Account of the Evaluation of 30 Diverse Pharmaceutical Compounds |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a The application of microcrystal electron diffraction (microED) to a variety of pharmaceutical compounds is reported. The examples and work detailed showcase the utility of microED as a routine technique for the rapid collection, analysis, and generation of structural data on a number of pharmaceutically relevant compounds, requiring minimal sample preparation and often without the need for time-consuming vitrification and cryo transfer processes. The development of a scripted data processing workflow allowed for simultaneous collection and processing of electron diffraction data, further expediting structural analysis of fifteen compounds. | ||
| 650 | 4 | |a Chemistry |7 (dpeaa)DE-84 | |
| 650 | 4 | |a 540 |7 (dpeaa)DE-84 | |
| 700 | 1 | |a Smith, Austin G. |e verfasserin |4 aut | |
| 700 | 1 | |a Caille, Seb |e verfasserin |4 aut | |
| 700 | 1 | |a Walker, Shawn D. |e verfasserin |4 aut | |
| 700 | 1 | |a Wurz, Ryan |e verfasserin |4 aut | |
| 700 | 1 | |a Cee, Victor J. |e verfasserin |4 aut | |
| 700 | 1 | |a Rodriguez, Jose |e verfasserin |4 aut | |
| 700 | 1 | |a Gostovic, D. |e verfasserin |4 aut | |
| 700 | 1 | |a Quasdorf, Kyle |e verfasserin |4 aut | |
| 700 | 1 | |a Nelson, Hosea M. |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t chemRxiv.org |g (2022) vom: 01. Feb. |
| 773 | 1 | 8 | |g year:2022 |g day:01 |g month:02 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.33774/chemrxiv-2021-h3tqz |z kostenfrei |3 Volltext |
| 912 | |a GBV_XCH | ||
| 912 | |a SSG-OLC-PHA | ||
| 951 | |a AR | ||
| 952 | |j 2022 |b 01 |c 02 | ||