Improved correction of<i>B</i><sub><i>0</i></sub>inhomogeneity-induced distortions in diffusion-weighted images of the prostate
Abstract Background Conventional distortion correction techniques include the Reversed Polarity Gradient (RPG) method and FSL-topup, which estimate tissue displacement from EPI images of opposite phase-encoding polarity, and scale image intensity by the Jacobian of the estimated displacement.Purpose To demonstrate that Jacobian intensity correction (JIC) can cause misleading improvement of EPI image distortion. We propose an alternative distortion correction approach (multi-bRPG; mRPG) that eliminates the JIC factor by normalizing opposite-polarity EPI images across multipleb-values.Study type Retrospective.Population 163 prostate cancer patients without metallic implants.Fieldstrength/Sequence 3T diffusion-weighted sequence with EPI readout, using multipleb-values.Assessment Maps of spatial shift (distortion) were estimated from opposite-polarity EPI volumes using RPG, topup, and mRPG. The estimated spatial shifts from each method were then applied to correct theb=0s/mm2images (both with and without JIC) and ADC maps (for which JIC is meaningless).Distortion was quantified by the Pearson correlation between opposite-polarity volumes. The distribution of correlation coefficients across all patients was examined forb=0s/mm2images and ADC maps, before and after distortion correction by each method. The mean, median, and 10thpercentile were reported for each distribution.Statistical tests Wilcoxon signed-rank tests (α=0.05) were used to assess whether correlation increased significantly after distortion correction by each method, and whether mRPG yielded a larger increase versus RPG or topup.Results Median improvement in the correlation betweenb=0s/mm2volumes was significantly smaller without JIC (p<0.001): 0.04 vs 0.16 (RPG), 0.06 vs 0.18 (topup). mRPG yielded significantly larger improvements compared to RPG or topup (p<0.001).b=0s/mm2: 0.09 vs 0.04 (RPG) and 0.06 (topup). ADC: 0.09 vs 0.02 (RPG) and 0.03 (topup).Data conclusion Disparity in the distortion-correction performance of conventional methods with and without JIC suggests underestimation of tissue displacement. mRPG shows improved correction of distortion artifacts compared to conventional methods..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
bioRxiv.org - (2024) vom: 30. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Conlin, Christopher C [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2024.03.26.24304935 |
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| PPN (Katalog-ID): |
XBI043084885 |
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| 100 | 1 | |a Conlin, Christopher C |e verfasserin |0 (orcid)0000-0003-4509-8702 |4 aut | |
| 245 | 1 | 0 | |a Improved correction of<i>B</i><sub><i>0</i></sub>inhomogeneity-induced distortions in diffusion-weighted images of the prostate |
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| 520 | |a Abstract Background Conventional distortion correction techniques include the Reversed Polarity Gradient (RPG) method and FSL-topup, which estimate tissue displacement from EPI images of opposite phase-encoding polarity, and scale image intensity by the Jacobian of the estimated displacement.Purpose To demonstrate that Jacobian intensity correction (JIC) can cause misleading improvement of EPI image distortion. We propose an alternative distortion correction approach (multi-bRPG; mRPG) that eliminates the JIC factor by normalizing opposite-polarity EPI images across multipleb-values.Study type Retrospective.Population 163 prostate cancer patients without metallic implants.Fieldstrength/Sequence 3T diffusion-weighted sequence with EPI readout, using multipleb-values.Assessment Maps of spatial shift (distortion) were estimated from opposite-polarity EPI volumes using RPG, topup, and mRPG. The estimated spatial shifts from each method were then applied to correct theb=0s/mm2images (both with and without JIC) and ADC maps (for which JIC is meaningless).Distortion was quantified by the Pearson correlation between opposite-polarity volumes. The distribution of correlation coefficients across all patients was examined forb=0s/mm2images and ADC maps, before and after distortion correction by each method. The mean, median, and 10thpercentile were reported for each distribution.Statistical tests Wilcoxon signed-rank tests (α=0.05) were used to assess whether correlation increased significantly after distortion correction by each method, and whether mRPG yielded a larger increase versus RPG or topup.Results Median improvement in the correlation betweenb=0s/mm2volumes was significantly smaller without JIC (p<0.001): 0.04 vs 0.16 (RPG), 0.06 vs 0.18 (topup). mRPG yielded significantly larger improvements compared to RPG or topup (p<0.001).b=0s/mm2: 0.09 vs 0.04 (RPG) and 0.06 (topup). ADC: 0.09 vs 0.02 (RPG) and 0.03 (topup).Data conclusion Disparity in the distortion-correction performance of conventional methods with and without JIC suggests underestimation of tissue displacement. mRPG shows improved correction of distortion artifacts compared to conventional methods. | ||
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