A mechanistic modeling approach to assessing the sensitivity of outcomes of water, sanitation, and hygiene interventions to local contexts and intervention factors

Abstract Background Diarrheal disease is a leading cause of morbidity and mortality in young children. Water, sanitation, and hygiene (WASH) improvements have historically been responsible for major public health gains by reducing exposure to enteropathogens, but many individual interventions have failed to consistently reduce diarrheal disease burden. Analytical tools that can estimate the potential impacts of individual WASH improvements in specific contexts would support program managers and policymakers to set targets that would yield health gains.Methods To understand the impact of WASH improvements on diarrhea, we developed a disease transmission model to simulate an intervention trial with a single intervention. We accounted for contextual factors, including preexisting WASH conditions and baseline disease prevalence, as well as intervention WASH factors, including community coverage, compliance, efficacy, and the intervenable fraction of transmission. We illustrated the sensitivity of intervention effectiveness to the contextual and intervention factors in each of two scenarios in which a 50% reduction in disease was achieved through a different combination of factors (higher preexisting WASH conditions, compliance, and intervenable fraction vs higher intervention efficacy and community coverage).Results Achieving disease elimination depended on more than one factor, and factors that could be used to achieve disease elimination in one scenario could be ineffective in the other scenario. Community coverage interacted strongly with both the contextual and intervention factors. For example, the positive impact of increasing intervention community coverage increased non-linearly with increasing intervention compliance. Additionally, counterfactually improving the contextual preexisting WASH conditions could have a positive or negative effect on the intervention effectiveness, depending on the values of other factors.Conclusions When developing interventions, it is important to account for both contextual conditions and the intervention parameters. Our mechanistic modeling approach can provide guidance for developing locally specific policy recommendations..

Medienart:	Preprint

Erscheinungsjahr:	2024
Erschienen:	2024

Enthalten in:	bioRxiv.org - (2024) vom: 14. März Zur Gesamtaufnahme - year:2024

Sprache:	Englisch

Beteiligte Personen:	Brouwer, Andrew F. [VerfasserIn] Kraay, Alicia N.M. [VerfasserIn] Zahid, Mondal H. [VerfasserIn] Eisenberg, Marisa C. [VerfasserIn] Freeman, Matthew C. [VerfasserIn] Eisenberg, Joseph N.S. [VerfasserIn]

Links:	Volltext [kostenfrei]

Themen:	570 Biology

doi:	10.1101/2024.03.09.24304020

funding:
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PPN (Katalog-ID):	XBI042884071