A complete mitochondrial genome of a Roman-era<i>Plasmodium falciparum</i>
Summary Malaria has historically been one of the leading infection-related causes of death in human populations. To this day, it continues to pose a significant public health threat in African countries, particularly among children. Humans are affected by fivePlasmodiumspecies, withPlasmodium falciparumbeing the most lethal. The study of pathogenic DNA from ancient human remains has been vital in understanding the origin, evolution, and virulence of human-infecting pathogens. However, there have been no complete pre-20th century mitochondrial DNA (mtDNA) or genomic sequences ofPlasmodium falciparumreported to date. This gap in knowledge makes it difficult to understand the genetic dynamics of this pathogen in the past. The difficulty in identifying ancient malaria cases through bioarchaeology and the infrequent presence ofPlasmodiumDNA in ancient bones contribute to these limitations. Here, we present the first complete mtDNA genome ofP. falciparumrecovered from an archaeological skeleton (a 2ndcentury CE Roman individual from Italy). The study of the 43-fold mtDNA genome supports the hypothesis of an Indian origin forP. falciparumin Europe and provides evidence for the genetic continuity of this lineage over the past 2,000 years. Additionally, our research highlights that extensive sampling may be necessary for malaria screening to gain insights into the evolution of this vector-borne disease from archaeological samples..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
bioRxiv.org - (2024) vom: 08. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Llanos-Lizcano, Alejandro [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2024.03.05.583465 |
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| PPN (Katalog-ID): |
XBI042818095 |
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| 520 | |a Summary Malaria has historically been one of the leading infection-related causes of death in human populations. To this day, it continues to pose a significant public health threat in African countries, particularly among children. Humans are affected by fivePlasmodiumspecies, withPlasmodium falciparumbeing the most lethal. The study of pathogenic DNA from ancient human remains has been vital in understanding the origin, evolution, and virulence of human-infecting pathogens. However, there have been no complete pre-20th century mitochondrial DNA (mtDNA) or genomic sequences ofPlasmodium falciparumreported to date. This gap in knowledge makes it difficult to understand the genetic dynamics of this pathogen in the past. The difficulty in identifying ancient malaria cases through bioarchaeology and the infrequent presence ofPlasmodiumDNA in ancient bones contribute to these limitations. Here, we present the first complete mtDNA genome ofP. falciparumrecovered from an archaeological skeleton (a 2ndcentury CE Roman individual from Italy). The study of the 43-fold mtDNA genome supports the hypothesis of an Indian origin forP. falciparumin Europe and provides evidence for the genetic continuity of this lineage over the past 2,000 years. Additionally, our research highlights that extensive sampling may be necessary for malaria screening to gain insights into the evolution of this vector-borne disease from archaeological samples. | ||
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