Transcription Factors with Broad Expression in the Zebrafish Spinal Cord
Abstract Background The spinal cord is a crucial part of the vertebrate central nervous system, controlling movements and receiving and processing sensory information from the trunk and limbs. However, there is much we do not know about how this essential organ develops. Here, we describe expression of 22 transcription factor genes in the zebrafish spinal cord.Results We analyzed the spinal cord expression of aurkb, foxb1a, foxb1b, her8a, homeza, ivns1abpb, mybl2b, myt1a, nr2f1b, onecut1, sall1a, sall3a, sall3b, sall4, sox2, sox19b, sp8b, tsc22d1, wdhd1, zfhx3b, znf804a, and znf1032 in wild-type and MIB E3 ubiquitin protein ligase 1 zebrafish embryos. While all of these genes are broadly expressed in the spinal cord, they have distinct expression patterns from one another. Some are predominanatly expressed in progenitor domains, and others in subsets of post-mitotic cells. Given the conservation of spinal cord development, and the transcription factors that regulate it, we expect that these genes will have similar spinal cord expression patterns in other vertebrates, including mammals and humans.Conclusions Our data identify 22 different transcription factors that are strong candidates for playing different roles in spinal cord development. For several of these genes, this is the first published description of their spinal cord expression..
| Medienart: |
|
|---|
Preprint| Erscheinungsjahr: |
2024 |
|---|---|
| Erschienen: |
2024 |
| Enthalten in: |
bioRxiv.org - (2024) vom: 17. Feb. Zur Gesamtaufnahme - year:2024 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
England, Samantha J. [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.1101/2024.02.14.580357 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
XBI042527287 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | XBI042527287 | ||
| 003 | DE-627 | ||
| 005 | 20240218090430.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 240216s2024 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1101/2024.02.14.580357 |2 doi | |
| 035 | |a (DE-627)XBI042527287 | ||
| 035 | |a (biorXiv)10.1101/2024.02.14.580357 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a England, Samantha J. |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Transcription Factors with Broad Expression in the Zebrafish Spinal Cord |
| 264 | 1 | |c 2024 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract Background The spinal cord is a crucial part of the vertebrate central nervous system, controlling movements and receiving and processing sensory information from the trunk and limbs. However, there is much we do not know about how this essential organ develops. Here, we describe expression of 22 transcription factor genes in the zebrafish spinal cord.Results We analyzed the spinal cord expression of aurkb, foxb1a, foxb1b, her8a, homeza, ivns1abpb, mybl2b, myt1a, nr2f1b, onecut1, sall1a, sall3a, sall3b, sall4, sox2, sox19b, sp8b, tsc22d1, wdhd1, zfhx3b, znf804a, and znf1032 in wild-type and MIB E3 ubiquitin protein ligase 1 zebrafish embryos. While all of these genes are broadly expressed in the spinal cord, they have distinct expression patterns from one another. Some are predominanatly expressed in progenitor domains, and others in subsets of post-mitotic cells. Given the conservation of spinal cord development, and the transcription factors that regulate it, we expect that these genes will have similar spinal cord expression patterns in other vertebrates, including mammals and humans.Conclusions Our data identify 22 different transcription factors that are strong candidates for playing different roles in spinal cord development. For several of these genes, this is the first published description of their spinal cord expression. | ||
| 650 | 4 | |a Biology |7 (dpeaa)DE-84 | |
| 650 | 4 | |a 570 |7 (dpeaa)DE-84 | |
| 700 | 1 | |a Campbell, Paul C. |4 aut | |
| 700 | 1 | |a Bates, Richard L. |4 aut | |
| 700 | 1 | |a Grieb, Ginny |4 aut | |
| 700 | 1 | |a Fancher, William F. |4 aut | |
| 700 | 1 | |a Lewis, Katharine E. |0 (orcid)0000-0002-3934-2281 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t bioRxiv.org |g (2024) vom: 17. Feb. |
| 773 | 1 | 8 | |g year:2024 |g day:17 |g month:02 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1101/2024.02.14.580357 |z kostenfrei |3 Volltext |
| 912 | |a GBV_XBI | ||
| 951 | |a AR | ||
| 952 | |j 2024 |b 17 |c 02 | ||