Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity
Abstract The adaptive T cell response is accompanied by continuous rewiring of the T cell’s electric and metabolic state. Ion channels and nutrient transporters integrate bioelectric and biochemical signals from the environment, setting cellular electric and metabolic states. Divergent electric and metabolic states contribute to T cell immunity or tolerance. Here, we report that neuritin (Nrn1) contributes to tolerance development by modulating regulatory and effector T cell function. Nrn1 expression in regulatory T cells promotes its expansion and suppression function, while expression in the T effector cell dampens its inflammatory response. Nrn1 deficiency causes dysregulation of ion channel and nutrient transporter expression in Treg and effector T cells, resulting in divergent metabolic outcomes and impacting autoimmune disease progression and recovery. These findings identify a novel immune function of the neurotrophic factor Nrn1 in regulating the T cell metabolic state in a cell context-dependent manner and modulating the outcome of an immune response..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
bioRxiv.org - (2024) vom: 06. Feb. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yu, Hong [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2024.01.31.578284 |
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| PPN (Katalog-ID): |
XBI04237782X |
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| 245 | 1 | 0 | |a Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity |
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| 520 | |a Abstract The adaptive T cell response is accompanied by continuous rewiring of the T cell’s electric and metabolic state. Ion channels and nutrient transporters integrate bioelectric and biochemical signals from the environment, setting cellular electric and metabolic states. Divergent electric and metabolic states contribute to T cell immunity or tolerance. Here, we report that neuritin (Nrn1) contributes to tolerance development by modulating regulatory and effector T cell function. Nrn1 expression in regulatory T cells promotes its expansion and suppression function, while expression in the T effector cell dampens its inflammatory response. Nrn1 deficiency causes dysregulation of ion channel and nutrient transporter expression in Treg and effector T cells, resulting in divergent metabolic outcomes and impacting autoimmune disease progression and recovery. These findings identify a novel immune function of the neurotrophic factor Nrn1 in regulating the T cell metabolic state in a cell context-dependent manner and modulating the outcome of an immune response. | ||
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| 700 | 1 | |a Nishio, Hiroshi |4 aut | |
| 700 | 1 | |a Barbi, Joseph |4 aut | |
| 700 | 1 | |a Mitchell-Flack, Marisa |4 aut | |
| 700 | 1 | |a Vignali, Paolo D. A. |4 aut | |
| 700 | 1 | |a Zheng, Ying |4 aut | |
| 700 | 1 | |a Lebid, Andriana |4 aut | |
| 700 | 1 | |a Chang, Kwang-Yu |4 aut | |
| 700 | 1 | |a Fu, Juan |4 aut | |
| 700 | 1 | |a Higgins, Makenzie |4 aut | |
| 700 | 1 | |a Huang, Ching-Tai |4 aut | |
| 700 | 1 | |a Zhang, Xuehong |4 aut | |
| 700 | 1 | |a Li, Zhiguang |4 aut | |
| 700 | 1 | |a Blosser, Lee |4 aut | |
| 700 | 1 | |a Tam, Ada |4 aut | |
| 700 | 1 | |a Drake, Charles G. |0 (orcid)0000-0001-9610-3677 |4 aut | |
| 700 | 1 | |a Pardoll, Drew M. |4 aut | |
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