Task Activation Results in Regional<sup>13</sup>C-Lactate Signal Increase in the Human Brain
Abstract Hyperpolarized-13C magnetic resonance imaging (HP-13C MRI) was used to image changes in13C-lactate signal during a visual stimulus condition in comparison to an eyes-closed control condition. Whole-brain13C-pyruvate,13C-lactate and13C-bicarbonate production was imaged in healthy volunteers (N=6, ages 24-33) for the two conditions using two separate hyperpolarized13C-pyruvate injections. BOLD-fMRI scans were used to delineate regions of functional activation.13C-metabolite signal was normalized by13C-metabolite signal from the brainstem and the percentage change in13C-metabolite signal conditions was calculated. A one-way Wilcoxon signed-rank test showed a significant increase in13C-lactate in regions of activation when compared to the remainder of the brain (p= 0.02, V = 21). No significant increase was observed in13C-pyruvate (p= 0.11, V = 17) or13C-bicarbonate (p= 0.95, V = 3) signal. The results show an increase in13C-lactate production in the activated region that is measurable with HP-13C MRI..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
bioRxiv.org - (2024) vom: 05. Feb. Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Uthayakumar, Biranavan [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2024.02.01.577808 |
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| PPN (Katalog-ID): |
XBI042371597 |
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| 520 | |a Abstract Hyperpolarized-13C magnetic resonance imaging (HP-13C MRI) was used to image changes in13C-lactate signal during a visual stimulus condition in comparison to an eyes-closed control condition. Whole-brain13C-pyruvate,13C-lactate and13C-bicarbonate production was imaged in healthy volunteers (N=6, ages 24-33) for the two conditions using two separate hyperpolarized13C-pyruvate injections. BOLD-fMRI scans were used to delineate regions of functional activation.13C-metabolite signal was normalized by13C-metabolite signal from the brainstem and the percentage change in13C-metabolite signal conditions was calculated. A one-way Wilcoxon signed-rank test showed a significant increase in13C-lactate in regions of activation when compared to the remainder of the brain (p= 0.02, V = 21). No significant increase was observed in13C-pyruvate (p= 0.11, V = 17) or13C-bicarbonate (p= 0.95, V = 3) signal. The results show an increase in13C-lactate production in the activated region that is measurable with HP-13C MRI. | ||
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