Progressively shifting patterns of co-modulation among premotor cortex neurons carry dynamically similar signals during action execution and observation

ABSTRACT Many neurons in the premotor cortex show firing rate modulation whether the subject performs an action or observes another individual performing a similar action. Although such “mirror neurons” have been thought to have highly congruent discharge during execution and observation, many if not most show non-congruent activity. Studies of such neuronal populations have shown that the most prevalent patterns of co-modulation—captured as neural trajectories—pass through subspaces which are shared in part, but in part are visited exclusively during either execution or observation. These studies focused on reaching movements for which low-dimensional neural trajectories exhibit comparatively simple dynamical motifs. But the neural dynamics of hand movements are more complex. We developed a novel approach to examine prevalent patterns of co-modulation during execution and observation of a task that involved reaching, grasping, and manipulation. Rather than following neural trajectories in subspaces that contain their entire time course, we identified time series of instantaneous subspaces, calculated principal angles among them, sampled trajectory segments at the times of selected behavioral events, and projected those segments into the series of instantaneous subspaces. We found that instantaneous neural subspaces generally remained distinct during execution versus observation. Nevertheless, execution and observation could be partially aligned with canonical correlation, indicating some dynamical similarity of the neural representations of different movements relative to one another during execution and observation which may enable the nervous system to recognize corresponding actions performed by the subject or by another individual and/or may reflect social interaction between the two. During action execution, mirror neurons showed consistent patterns of co-modulation both within and between sessions, but other neurons that were modulated only during action execution and not during observation showed considerable variability of co-modulation. We speculate that during execution, mirror neurons carry a consistent forward model of the intended movement, while action-execution only neurons process more variable feedback..

Medienart:	Preprint

Erscheinungsjahr:	2024
Erschienen:	2024

Enthalten in:	bioRxiv.org - (2024) vom: 16. Apr. Zur Gesamtaufnahme - year:2024

Sprache:	Englisch

Beteiligte Personen:	Zhao, Zhonghao [VerfasserIn] Schieber, Marc H. [VerfasserIn]

Links:	Volltext [kostenfrei]

Themen:	570 Biology

doi:	10.1101/2023.11.06.565833

funding:
Förderinstitution / Projekttitel:

PPN (Katalog-ID):	XBI041450337