An algorithm to build synthetic temporal contact networks based on close-proximity interactions data

Abstract Small populations (e.g., hospitals, schools or workplaces) are characterised by high contact heterogeneity and stochasticity affecting pathogen transmission dynamics. Empirical individual contact data provide unprecedented information to characterize such heterogeneity and are increasingly available, but are usually collected over a limited period, and can suffer from observation bias. We propose an algorithm to stochastically reconstruct realistic temporal networks from individual contact data in healthcare settings (HCS) and test this approach using real data previously collected in a long-term care facility (LTCF).Our algorithm generates full networks from recorded close-proximity interactions, using hourly inter-individual contact rates and information on individuals’ wards, the categories of staff involved in contacts, and the frequency of recurring contacts. It also provides data augmentation by reconstructing contacts for days when some individuals are present in the HCS without having contacts recorded in the empirical data. Recording bias is formalized through an observation model, to allow direct comparison between the augmented and observed networks. We validate our algorithm using data collected during the i-Bird study, and compare the empirical and reconstructed networks.The algorithm was substantially more accurate to reproduce network characteristics than random graphs. The reconstructed networks reproduced well the assortativity by ward (first– third quartiles observed: 0.54–0.64; synthetic: 0.52–0.64) and the hourly staff and patient contact patterns. Importantly, the observed temporal correlation was also well reproduced (0.39–0.50 vs 0.37–0.44), indicating that our algorithm could recreate a realistic temporal structure. The algorithm consistently recreated unobserved contacts to generate full reconstructed networks for the LTCF.To conclude, we propose an approach to generate realistic temporal contact networks and reconstruct unobserved contacts from summary statistics computed using individual-level interaction networks. This could be applied and extended to generate contact networks to other HCS using limited empirical data, to subsequently inform individual-based epidemic models.Author summary Contact networks are the most informative representation of the contact heterogeneity, and therefore infectious disease transmission risk, in small populations. However, the data collection required is costly and complex, usually limited to a few days only and likely to suffer from partially observed data, making the practical integration of networks into models challenging. In this article, we present an approach leveraging empirical individual contact data to stochastically reconstruct realistic temporal networks in healthcare settings. The algorithm accounts for population specificities including the hourly distribution of contact rates between different individuals (staff categories, patients) and the probability for contact repetition between the same individuals. We illustrate and validate this algorithm using a real contact network measured in a long-term care facility. Our approach outperforms random graphs informed by the same data to accurately reproduce observed network characteristics and hourly staff-patient contact patterns. The algorithm recreates unobserved contacts, providing data augmentation for times with missing information. This method should improve the usability and reliability of contact networks, and therefore promote integration of empiric contact data in individual-based models..

Medienart:	Preprint

Erscheinungsjahr:	2023
Erschienen:	2023

Enthalten in:	bioRxiv.org - (2023) vom: 12. Dez. Zur Gesamtaufnahme - year:2023

Sprache:	Englisch

Beteiligte Personen:	Duval, Audrey [VerfasserIn] Leclerc, Quentin [VerfasserIn] Guillemot, Didier [VerfasserIn] Temime, Laura [VerfasserIn] Opatowski, Lulla [VerfasserIn]

Links:	Volltext [kostenfrei]

Themen:	570 Biology

doi:	10.1101/2023.10.23.23296945

funding:
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PPN (Katalog-ID):	XBI041308654