Molecular Landscape and Contemporary Prognostic Signatures of Gliomas
Abstract Molecularly-driven treatments are expanding options for patients with gliomas, driving a need for molecularly-informed prognostic information. To characterize the genomic landscape and contemporary outcomes of gliomas, we analyzed 4,400 gliomas from multi-institutional datasets and The Cancer Genome Atlas (TCGA): 2,195 glioblastoma, 1,198IDH1/2-mutant astrocytoma, 531 oligodendroglioma, 271 otherIDH1/2-wildtype glioma, and 205 pediatric-type glioma. Molecular classification updated 27.4% of gliomas from their original histopathologic diagnosis. Canonical alterations helped categorize glioma subtypes, revealing mutually exclusive alterations within tumorigenic pathways. Across each glioma subtype, non-TCGA patients had longer survival compared to TCGA patients. Several novel prognostic alterations emerged, includingNF1alteration and 21q loss in glioblastoma, andEGFRamplification and 22q loss inIDH1/2-mutant astrocytoma. Certain prognostic features varied across age, with decreasing prevalence ofIDH1/2-mutation over time whileMGMT-methylation remained steady. Our findings provide a framework for further exploration and validation of glioma prognostic indicators in clinically representative cohorts and trials..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
bioRxiv.org - (2023) vom: 14. Sept. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ghosh, Hia S. [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2023.09.09.23295096 |
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| PPN (Katalog-ID): |
XBI040808327 |
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| 520 | |a Abstract Molecularly-driven treatments are expanding options for patients with gliomas, driving a need for molecularly-informed prognostic information. To characterize the genomic landscape and contemporary outcomes of gliomas, we analyzed 4,400 gliomas from multi-institutional datasets and The Cancer Genome Atlas (TCGA): 2,195 glioblastoma, 1,198IDH1/2-mutant astrocytoma, 531 oligodendroglioma, 271 otherIDH1/2-wildtype glioma, and 205 pediatric-type glioma. Molecular classification updated 27.4% of gliomas from their original histopathologic diagnosis. Canonical alterations helped categorize glioma subtypes, revealing mutually exclusive alterations within tumorigenic pathways. Across each glioma subtype, non-TCGA patients had longer survival compared to TCGA patients. Several novel prognostic alterations emerged, includingNF1alteration and 21q loss in glioblastoma, andEGFRamplification and 22q loss inIDH1/2-mutant astrocytoma. Certain prognostic features varied across age, with decreasing prevalence ofIDH1/2-mutation over time whileMGMT-methylation remained steady. Our findings provide a framework for further exploration and validation of glioma prognostic indicators in clinically representative cohorts and trials. | ||
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| 700 | 1 | |a Bhave, Varun M. |4 aut | |
| 700 | 1 | |a Maury, Eduardo A. |0 (orcid)0000-0002-2211-8611 |4 aut | |
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| 700 | 1 | |a Hoffman, Samantha E. |4 aut | |
| 700 | 1 | |a Li, Yvonne |4 aut | |
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| 700 | 1 | |a Vogelzang, Jayne |4 aut | |
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| 700 | 1 | |a Dubois, Frank |4 aut | |
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| 700 | 1 | |a Bi, Wenya Linda |4 aut | |
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