Alterations in Sarcopenia Index are Associated with Inflammation, Gut and Oral Microbiota among Heart Failure, Left Ventricular Assist Device and Heart Transplant Patients

ABSTRACT Background Sarcopenia, characterized by loss of muscle mass and function, is prevalent in heart failure (HF) and associated with poor outcomes. We investigated alterations in sarcopenia index (SI), a surrogate marker of skeletal muscle mass, in HF, left ventricular assist device (LVAD) and heart transplant (HT) and assessed its relationship with inflammation and digestive tract (gut and oral) microbiota.Methods We enrolled 460 HF, LVAD and HT patients. Repeated measures pre and post procedures were obtained in a subset of LVAD and HT patients. Sarcopenia index (serum Creatinine/Cystatin C) and inflammatory biomarkers (C-reactive protein, interleukin-6, tumor necrosis factor-alpha) were measured in 271 and 622 blood samples, respectively. Gut and saliva microbiota were assessed via 16S rRNA sequencing among 335 stool and 341 saliva samples. Multivariable regression models were used to assess the relationship between SI and i) New York Heart Association class; ii) pre-vs. post-LVAD or HT; iii) biomarkers of inflammation and microbial diversity.Results Median (interquartile range) ln-SI was −0.13(−0.32,0.05). Ln-SI decreased across worsening HF class, further declined within the 1-month after LVAD and HT and rebounded over time to the levels of symptomatic HF. Ln-SI demonstrated an inverse correlation with inflammation (r=-0.28, p<0.0001), and a positive correlation with gut (r=0.26, p<0.0001) and oral microbial diversity (r=0.24, p<0.0001). Presence of the gut taxaRoseburia inulinivoranswas associated with increased SI.Conclusions SI levels decreased in symptomatic HF and remained decreased long-term after LVAD and HT. SI levels covaried with inflammation, gut and oral microbiota in a similar fashion..

Medienart:	Preprint

Erscheinungsjahr:	2023
Erschienen:	2023

Enthalten in:	bioRxiv.org - (2023) vom: 20. Dez. Zur Gesamtaufnahme - year:2023

Sprache:	Englisch

Beteiligte Personen:

Yuzefpolskaya, Melana [VerfasserIn] Bohn, Bruno [VerfasserIn] Ladanyi, Annamaria [VerfasserIn] Pinsino, Alberto [VerfasserIn] Braghieri, Lorenzo [VerfasserIn] Carey, Matthew R. [VerfasserIn] Clerkin, Kevin [VerfasserIn] Sayer, Gabriel T. [VerfasserIn] Latif, Farhana [VerfasserIn] Koji, Takeda [VerfasserIn] Uriel, Nir [VerfasserIn] Nandakumar, Renu [VerfasserIn] Uhlemann, Anne-Catrin [VerfasserIn] Colombo, Paolo C. [VerfasserIn] Demmer, Ryan T. [VerfasserIn]

Links:	Volltext [kostenfrei]

Themen:	570 Biology

doi:	10.1101/2023.08.30.23294874

funding:
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PPN (Katalog-ID):	XBI040701859