MEX-PD: A National Network for the Epidemiological & Genetic Research of Parkinson’s Disease
Abstract Background Parkinson’s Disease (PD) has a complex etiology, involving genetic and environmental factors. Most of our current understanding of the disease comes from studies in populations with mostly European ancestry, representing challenges in generalizing findings to other populations with different genetic, social, and environmental contexts. There are scarce studies focused in Latin American populations. The Mexican population is genetically diverse because its admixture from Native American, European, and African ancestries, coupled with the unique environmental conditions, stressing the relevance of establishing genetic studies in this population. Thus, we have established theMexican Parkinson’s Research Network(MEX-PD), a consortium to research the clinical, genetical, environmental, and neurophysiological bases of the phenotypic diversity in Mexican PD patients.Objectives Describing how MEX-PD was established, the methods and instruments and presenting the first results.Methods Patients and controls were recruited from medical centers in 20 states of Mexico. Initial recruitment included neurological evaluation, cognitive assessment, and DNA collection.Results MEX-PD has registered 302 controls and 262 PD patients with a mean age of diagnosis of 61 years (SD=10.86). There were 19.8% PD patients identified with early onset. Levodopa was the most common pharmacological treatment.Conclusions MEX-PD contributes to understand PD nationally. The information gathered here will allow us to understand the prevalence of mental health, neurological symptoms, and cognitive function in the PD Mexican population and how genetical and environmental factors contributes to those outcomes. These will advocate for personalized treatments and improving quality of life in the Mexican population..
| Medienart: |
|
|---|
Preprint| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
bioRxiv.org - (2023) vom: 20. Dez. Zur Gesamtaufnahme - year:2023 |
|---|
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Lázaro-Figueroa, Alejandra [VerfasserIn] |
|---|
| Links: |
Volltext [kostenfrei] |
|---|
| Themen: |
|---|
| doi: |
10.1101/2023.08.28.23294700 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
XBI040701824 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | XBI040701824 | ||
| 003 | DE-627 | ||
| 005 | 20231221091030.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230901s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1101/2023.08.28.23294700 |2 doi | |
| 035 | |a (DE-627)XBI040701824 | ||
| 035 | |a (biorXiv)10.1101/2023.08.28.23294700 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Lázaro-Figueroa, Alejandra |e verfasserin |0 (orcid)0009-0009-0448-0287 |4 aut | |
| 245 | 1 | 0 | |a MEX-PD: A National Network for the Epidemiological & Genetic Research of Parkinson’s Disease |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 520 | |a Abstract Background Parkinson’s Disease (PD) has a complex etiology, involving genetic and environmental factors. Most of our current understanding of the disease comes from studies in populations with mostly European ancestry, representing challenges in generalizing findings to other populations with different genetic, social, and environmental contexts. There are scarce studies focused in Latin American populations. The Mexican population is genetically diverse because its admixture from Native American, European, and African ancestries, coupled with the unique environmental conditions, stressing the relevance of establishing genetic studies in this population. Thus, we have established theMexican Parkinson’s Research Network(MEX-PD), a consortium to research the clinical, genetical, environmental, and neurophysiological bases of the phenotypic diversity in Mexican PD patients.Objectives Describing how MEX-PD was established, the methods and instruments and presenting the first results.Methods Patients and controls were recruited from medical centers in 20 states of Mexico. Initial recruitment included neurological evaluation, cognitive assessment, and DNA collection.Results MEX-PD has registered 302 controls and 262 PD patients with a mean age of diagnosis of 61 years (SD=10.86). There were 19.8% PD patients identified with early onset. Levodopa was the most common pharmacological treatment.Conclusions MEX-PD contributes to understand PD nationally. The information gathered here will allow us to understand the prevalence of mental health, neurological symptoms, and cognitive function in the PD Mexican population and how genetical and environmental factors contributes to those outcomes. These will advocate for personalized treatments and improving quality of life in the Mexican population. | ||
| 650 | 4 | |a Biology |7 (dpeaa)DE-84 | |
| 650 | 4 | |a 570 |7 (dpeaa)DE-84 | |
| 700 | 1 | |a Reyes-Pérez, Paula |0 (orcid)0000-0001-8062-7441 |4 aut | |
| 700 | 1 | |a Morelos-Figaredo, Eugenia |0 (orcid)0000-0003-1698-2689 |4 aut | |
| 700 | 1 | |a Guerra-Galicia, Carlos M. |0 (orcid)0000-0002-9233-0511 |4 aut | |
| 700 | 1 | |a Estrada-Bellmann, Ingrid |0 (orcid)0000-0002-7812-0462 |4 aut | |
| 700 | 1 | |a Salinas-Barboza, Karla |0 (orcid)0000-0003-0366-8172 |4 aut | |
| 700 | 1 | |a Matuk-Pérez, Yamil |4 aut | |
| 700 | 1 | |a Gandarilla-Martínez, Nadia A. |0 (orcid)0000-0003-4465-9870 |4 aut | |
| 700 | 1 | |a Caballero-Sánchez, Ulises |0 (orcid)0000-0003-0490-7569 |4 aut | |
| 700 | 1 | |a Flores-Ocampo, Victor |0 (orcid)0009-0006-5562-1260 |4 aut | |
| 700 | 1 | |a Montés-Alcántara, Pablo |0 (orcid)0009-0009-5645-9156 |4 aut | |
| 700 | 1 | |a Espinosa-Méndez, Ian M. |0 (orcid)0009-0004-4789-6016 |4 aut | |
| 700 | 1 | |a Zayas-Del Moral, Alejandra |0 (orcid)0000-0001-5459-9205 |4 aut | |
| 700 | 1 | |a Gaspar-Martínez, Edith |0 (orcid)0009-0001-1952-9292 |4 aut | |
| 700 | 1 | |a Vazquez-Guevara, Damaris |0 (orcid)0000-0001-8809-0714 |4 aut | |
| 700 | 1 | |a Rodríguez-Violante, Mayela |0 (orcid)0000-0002-6041-9941 |4 aut | |
| 700 | 1 | |a Inca-Martinez, Miguel |0 (orcid)0000-0003-3770-0476 |4 aut | |
| 700 | 1 | |a Mata, Ignacio F. |0 (orcid)0000-0003-1198-0633 |4 aut | |
| 700 | 1 | |a Alcauter, Sarael |0 (orcid)0000-0001-8182-6370 |4 aut | |
| 700 | 1 | |a Rentería, Miguel E. |0 (orcid)0000-0003-4626-7248 |4 aut | |
| 700 | 1 | |a Medina-Rivera, Alejandra |0 (orcid)0000-0002-7912-2718 |4 aut | |
| 700 | 1 | |a Ruiz-Contreras, Alejandra E. |0 (orcid)0000-0002-9829-7636 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t bioRxiv.org |g (2023) vom: 20. Dez. |
| 773 | 1 | 8 | |g year:2023 |g day:20 |g month:12 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1101/2023.08.28.23294700 |z kostenfrei |3 Volltext |
| 912 | |a GBV_XBI | ||
| 951 | |a AR | ||
| 952 | |j 2023 |b 20 |c 12 | ||