Intermodal consistency of whole-brain connectivity and signal propagation delays
Abstract Measuring the propagation of perturbations across the human brain and their transmission delays is critical for network neuroscience, but it is a challenging problem that still requires cross-validation approaches. Here, we compare results from a recently introduced, non-invasive technique of functional delays estimation from source-reconstructed electro/magnetoencephalography, to the corresponding findings from a large dataset of cortico-cortical evoked potentials estimated from intracerebral stimulations of epileptic pharmaco-resistant patients. The two methods yield significantly similar probabilistic connectivity maps and signal propagation delays. This similarity suggests a correspondence between the mechanisms underpinning the propagation of spontaneously generated scale-free perturbations (i.e. neuronal avalanches observed in resting state activity studied using magnetoencephalography) and the spreading of cortico-cortical evoked potentials. This manuscript provides evidence for the accuracy of a subject-specific estimate of functional delays obtained non-invasively from reconstructed sources. Conversely, our findings show that estimates obtained from externally-induced perturbations capture physiological activities. In conclusion, this manuscript constitutes a cross-validation between two different modalities. Importantly, the capability to measure delays non-invasively (as per MEG) paves the way for the inclusion of functional delays in personalized large-scale brain models as well as in diagnostic and prognostic algorithms..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
bioRxiv.org - (2023) vom: 02. Sept. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Jedynak, Maciej [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2023.08.28.555074 |
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| PPN (Katalog-ID): |
XBI040675483 |
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| 520 | |a Abstract Measuring the propagation of perturbations across the human brain and their transmission delays is critical for network neuroscience, but it is a challenging problem that still requires cross-validation approaches. Here, we compare results from a recently introduced, non-invasive technique of functional delays estimation from source-reconstructed electro/magnetoencephalography, to the corresponding findings from a large dataset of cortico-cortical evoked potentials estimated from intracerebral stimulations of epileptic pharmaco-resistant patients. The two methods yield significantly similar probabilistic connectivity maps and signal propagation delays. This similarity suggests a correspondence between the mechanisms underpinning the propagation of spontaneously generated scale-free perturbations (i.e. neuronal avalanches observed in resting state activity studied using magnetoencephalography) and the spreading of cortico-cortical evoked potentials. This manuscript provides evidence for the accuracy of a subject-specific estimate of functional delays obtained non-invasively from reconstructed sources. Conversely, our findings show that estimates obtained from externally-induced perturbations capture physiological activities. In conclusion, this manuscript constitutes a cross-validation between two different modalities. Importantly, the capability to measure delays non-invasively (as per MEG) paves the way for the inclusion of functional delays in personalized large-scale brain models as well as in diagnostic and prognostic algorithms. | ||
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| 700 | 1 | |a Romano, Antonella |0 (orcid)0000-0003-3076-9665 |4 aut | |
| 700 | 1 | |a Jirsa, Viktor |0 (orcid)0000-0002-8251-8860 |4 aut | |
| 700 | 1 | |a David, Olivier |4 aut | |
| 700 | 1 | |a Sorrentino, Pierpaolo |0 (orcid)0000-0002-9556-9800 |4 aut | |
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