The Lifespan Trajectories of Brain Activities Related to Cognitive Control
Abstract Cognitive control plays a pivotal role in guiding human goal-directed behavior, and revealing its lifespan trajectory is crucial for optimizing cognitive functioning at different ages, especially for stages of rapid development and decline. While existing studies have shed light on the inverted U-shaped trajectory of cognitive control function both behaviorally and anatomically, little is known about the corresponding changes in functional brain activation with age. To bridge this gap, we conducted a comprehensive meta-analysis of 129 neuroimaging studies using conflict tasks, encompassing 3,388 participants whose age spanned from 5 to 85 years old. We applied the seed-baseddmapping (SDM), generalized additive model (GAM) and model comparison approaches to investigate age-related changes of brain activity, chart the lifespan trajectories and pinpoint peaks of cognitive control brain activity. The present study have three major findings: 1) The inverted U-shaped lifespan trajectory is the predominant pattern; 2) Cognitive control related brain regions exhibit heterogeneous lifespan trajectories: the frontoparietal control network (such as the inferior frontal gyrus and inferior parietal lobule) follows inverted U-shaped trajectories, peaking between 24 and 41 years, while the dorsal attention network (such as the frontal eye field and superior parietal lobule) demonstrates flatter trajectories with age; 3) Both the youth and the elderly show weaker brain activities and greater left laterality than young adults. These results collectively reveal the lifespan trajectories of cognitive control, highlighting heterogeneous fluctuations in brain networks with age..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
bioRxiv.org - (2024) vom: 18. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Zhenghan [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2023.08.20.554018 |
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XBI04058738X |
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| 520 | |a Abstract Cognitive control plays a pivotal role in guiding human goal-directed behavior, and revealing its lifespan trajectory is crucial for optimizing cognitive functioning at different ages, especially for stages of rapid development and decline. While existing studies have shed light on the inverted U-shaped trajectory of cognitive control function both behaviorally and anatomically, little is known about the corresponding changes in functional brain activation with age. To bridge this gap, we conducted a comprehensive meta-analysis of 129 neuroimaging studies using conflict tasks, encompassing 3,388 participants whose age spanned from 5 to 85 years old. We applied the seed-baseddmapping (SDM), generalized additive model (GAM) and model comparison approaches to investigate age-related changes of brain activity, chart the lifespan trajectories and pinpoint peaks of cognitive control brain activity. The present study have three major findings: 1) The inverted U-shaped lifespan trajectory is the predominant pattern; 2) Cognitive control related brain regions exhibit heterogeneous lifespan trajectories: the frontoparietal control network (such as the inferior frontal gyrus and inferior parietal lobule) follows inverted U-shaped trajectories, peaking between 24 and 41 years, while the dorsal attention network (such as the frontal eye field and superior parietal lobule) demonstrates flatter trajectories with age; 3) Both the youth and the elderly show weaker brain activities and greater left laterality than young adults. These results collectively reveal the lifespan trajectories of cognitive control, highlighting heterogeneous fluctuations in brain networks with age. | ||
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| 700 | 1 | |a Wang, Lingxiao |4 aut | |
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| 700 | 1 | |a Yang, Guochun |0 (orcid)0000-0002-0516-8772 |4 aut | |
| 700 | 1 | |a Liu, Xun |4 aut | |
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