Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region
High-dimensional brain activity is often organized into lower-dimensional neural manifolds. However, the neural manifolds of the visual cortex remain understudied. Here, we study large-scale multielectrode electrophysiological recordings of macaque (Macaca mulatta) areas V1, V4 and DP with a high spatio-temporal resolution. We find, for the first time, that the population activity of V1 contains two separate neural manifolds, which correlate strongly with eye closure (eyes open/closed) and have distinct dimensionalities. Moreover, we find strong top-down signals from V4 to V1, particularly to the foveal region of V1, which are significantly stronger during the eyes-open periods, a previously unknown effect. Finally,in silicosimulations of a balanced spiking neuron network qualitatively reproduce the experimental findings. Taken together, our analyses and simulations suggest that top-down signals modulate the population activity of V1, causing two distinct neural manifolds. We postulate that the top-down modulation during the eyes-open periods prepares V1 for fast and efficient visual responses, resulting in a type of visual stand-by state..
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Preprint| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
bioRxiv.org - (2024) vom: 29. März Zur Gesamtaufnahme - year:2024 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Morales-Gregorio, Aitor [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2023.06.14.544966 |
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| PPN (Katalog-ID): |
XBI039918033 |
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| 100 | 1 | |a Morales-Gregorio, Aitor |e verfasserin |0 (orcid)0000-0002-2403-928X |4 aut | |
| 245 | 1 | 0 | |a Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region |
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| 520 | |a High-dimensional brain activity is often organized into lower-dimensional neural manifolds. However, the neural manifolds of the visual cortex remain understudied. Here, we study large-scale multielectrode electrophysiological recordings of macaque (Macaca mulatta) areas V1, V4 and DP with a high spatio-temporal resolution. We find, for the first time, that the population activity of V1 contains two separate neural manifolds, which correlate strongly with eye closure (eyes open/closed) and have distinct dimensionalities. Moreover, we find strong top-down signals from V4 to V1, particularly to the foveal region of V1, which are significantly stronger during the eyes-open periods, a previously unknown effect. Finally,in silicosimulations of a balanced spiking neuron network qualitatively reproduce the experimental findings. Taken together, our analyses and simulations suggest that top-down signals modulate the population activity of V1, causing two distinct neural manifolds. We postulate that the top-down modulation during the eyes-open periods prepares V1 for fast and efficient visual responses, resulting in a type of visual stand-by state. | ||
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| 700 | 1 | |a Kurth, Anno C. |0 (orcid)0000-0002-9557-1003 |4 aut | |
| 700 | 1 | |a Ito, Junji |0 (orcid)0000-0001-9170-4422 |4 aut | |
| 700 | 1 | |a Kleinjohann, Alexander |0 (orcid)0000-0003-3776-4226 |4 aut | |
| 700 | 1 | |a Barthélemy, Frédéric V. |0 (orcid)0000-0003-2754-5142 |4 aut | |
| 700 | 1 | |a Brochier, Thomas |0 (orcid)0000-0001-6948-1234 |4 aut | |
| 700 | 1 | |a Grün, Sonja |0 (orcid)0000-0003-2829-2220 |4 aut | |
| 700 | 1 | |a van Albada, Sacha J. |0 (orcid)0000-0003-0682-4855 |4 aut | |
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