Low to moderate genetic influences on the rapid smell test SCENTinel™
Abstract SCENTinel™- a rapid, inexpensive smell test that measures odor detection, intensity, identification, and pleasantness - was developed for population-wide screening of smell function. SCENTinel™was previously found to screen for multiple types of smell disorders. However, the effect of genetic variability on SCENTinel™test performance is unknown, which could affect the test’s validity. This study assessed performance of SCENTinel™in a large group of individuals with a normal sense of smell to determine the test-retest reliability and the heritability of SCENTinel™test performance. One thousand participants (36 [IQR 26-52] years old, 72% female, 80% white) completed a SCENTinel™test at the 2021 and 2022 Twins Days Festivals in Twinsburg, OH, and 118 of those completed a SCENTinel™test on each of the festival’s two days. Participants comprised 55% percent monozygotic twins, 13% dizygotic twins, 0.4% triplets, and 36% singletons. We found that 97% of participants passed the SCENTinel™test. Test-retest reliability ranged from 0.57 to 0.71 for SCENTinel™subtests. Broad-sense heritability, based on 246 monozygotic and 62 dizygotic twin dyads, was low for odor intensity (r=0.03) and moderate for odor pleasantness (r=0.4). Together, this study suggests that SCENTinel™is a reliable smell test with only moderate heritability effects, which further supports its utility for population-wide screening for smell function..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
bioRxiv.org - (2023) vom: 13. Dez. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hunter, Stephanie R. [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2023.05.14.23289965 |
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| PPN (Katalog-ID): |
XBI039625907 |
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| 520 | |a Abstract SCENTinel™- a rapid, inexpensive smell test that measures odor detection, intensity, identification, and pleasantness - was developed for population-wide screening of smell function. SCENTinel™was previously found to screen for multiple types of smell disorders. However, the effect of genetic variability on SCENTinel™test performance is unknown, which could affect the test’s validity. This study assessed performance of SCENTinel™in a large group of individuals with a normal sense of smell to determine the test-retest reliability and the heritability of SCENTinel™test performance. One thousand participants (36 [IQR 26-52] years old, 72% female, 80% white) completed a SCENTinel™test at the 2021 and 2022 Twins Days Festivals in Twinsburg, OH, and 118 of those completed a SCENTinel™test on each of the festival’s two days. Participants comprised 55% percent monozygotic twins, 13% dizygotic twins, 0.4% triplets, and 36% singletons. We found that 97% of participants passed the SCENTinel™test. Test-retest reliability ranged from 0.57 to 0.71 for SCENTinel™subtests. Broad-sense heritability, based on 246 monozygotic and 62 dizygotic twin dyads, was low for odor intensity (r=0.03) and moderate for odor pleasantness (r=0.4). Together, this study suggests that SCENTinel™is a reliable smell test with only moderate heritability effects, which further supports its utility for population-wide screening for smell function. | ||
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