Racial/ethnic disparities in cardiovascular disease mortality attributable to long-term PM_2.5exposure in the United States from 2001 to 2016

Abstract Background The average concentration of fine particulate matter (PM2.5) has decreased in the U.S. in recent years. However, the health benefits of this improvement among different racial/ethnic groups are not known. This study aimed to estimate the associations between long-term exposure to ambient PM2.5and cause-specific cardiovascular disease (CVD) mortality rate and assess the PM2.5-attributable CVD deaths in non-Hispanic White, non-Hispanic Black, and Hispanic people across all counties in the contiguous U.S. from 2001 to 2016.Methods Using nationwide CVD mortality data for all ages obtained from National Center for Health Statistics, this study applied interactive fixed effects models to estimate the associations between 12-month moving average of PM2.5concentrations and monthly age-adjusted CVD mortality rates by race/ethnicity, controlling for both measured and unmeasured spatiotemporal confounders. Mortality from major types of CVD (ischemic heart disease [IHD], myocardial infarction [MI], stroke, hypertensive disease, and hypertensive heart disease) was also studied. We then calculated the burden of PM2.5-attributable CVD deaths in different race/ethnicity groups and examined the magnitude of racial/ethnic disparity and its changes over time.Results A total of 13,289,147 CVD deaths were included in the study. Each 1-µg/m3increase in 12-month moving average of PM2.5concentration was associated with increases of 7.16 (95% confidence interval [CI]: 3.81, 10.51) CVD deaths per 1,000,000 Black people per month, significantly higher than the estimates for non-Hispanic White people (Pvalue: 0.002). The higher vulnerability in non-Hispanic Black people was also observed for mortality from IHD, MI, and stroke. Long-term PM2.5exposure contributed to approximately 75.47 (95% CI: 40.14, 110.80) CVD deaths per 1,000,000 non-Hispanic Black people annually, over 3 times higher than the estimated rate in non-Hispanic White people (16.89, 95% CI:13.17, 20.62). From 2001 to 2016, the difference in attributable CVD mortality rate between Black and White people reduced by 44.04% (from 75.80 to 42.42 per 1,000,000 people), but the burden in Black people was still over 3 times higher compared to White people.Conclusions Non-Hispanic Black people have the highest PM2.5-attributable CVD mortality burden. Although the racial/ethnic disparity in this burden was narrowed over time, the gap between racial/ethnic minorities and non-Hispanic White people remains substantial..

Medienart:	Preprint

Erscheinungsjahr:	2023
Erschienen:	2023

Enthalten in:	bioRxiv.org - (2023) vom: 18. Feb. Zur Gesamtaufnahme - year:2023

Sprache:	Englisch

Beteiligte Personen:	Ma, Yiqun [VerfasserIn] Zang, Emma [VerfasserIn] Opara, Ijeoma [VerfasserIn] Lu, Yuan [VerfasserIn] Krumholz, Harlan M. [VerfasserIn] Chen, Kai [VerfasserIn]

Links:	Volltext [kostenfrei]

Themen:	570 Biology

doi:	10.1101/2022.09.07.22279640

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PPN (Katalog-ID):	XBI037244167