Tecovirimat is highly efficient on the Monkeypox virus lineage responsible for the international 2022 outbreak
Abstract The ongoing monkeypox virus (MPXV) outbreak is the largest ever recorded outside of Africa. Genomic analysis revealed a divergent phylogenetic lineage within clade 3, and atypical clinical presentations have been noted. We report the sequencing and isolation of the virus from the first clinical case diagnosed in France in May 2022. We tested thein vitroeffect of tecovirimat (ST-246), a FDA approved drug, against this novel strain, showing efficacy at the nanomolar range. In comparison, cidofovir showed activity at micromolar concentrations. These results and the safety profile of tecovirimat strongly support its use in clinical care of severe forms for the 2022 MPXV outbreak..
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Preprint| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
bioRxiv.org - (2023) vom: 12. Feb. Zur Gesamtaufnahme - year:2023 |
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| Sprache: |
Englisch |
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| Beteiligte Personen: |
Frenois-Veyrat, Gaëlle [VerfasserIn] |
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| Links: |
Volltext [kostenfrei] |
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| doi: |
10.1101/2022.07.19.500484 |
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| PPN (Katalog-ID): |
XBI036576468 |
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| 520 | |a Abstract The ongoing monkeypox virus (MPXV) outbreak is the largest ever recorded outside of Africa. Genomic analysis revealed a divergent phylogenetic lineage within clade 3, and atypical clinical presentations have been noted. We report the sequencing and isolation of the virus from the first clinical case diagnosed in France in May 2022. We tested thein vitroeffect of tecovirimat (ST-246), a FDA approved drug, against this novel strain, showing efficacy at the nanomolar range. In comparison, cidofovir showed activity at micromolar concentrations. These results and the safety profile of tecovirimat strongly support its use in clinical care of severe forms for the 2022 MPXV outbreak. | ||
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| 700 | 1 | |a Gorgé, Olivier |4 aut | |
| 700 | 1 | |a Marcheteau, Elie |4 aut | |
| 700 | 1 | |a Ferraris, Olivier |4 aut | |
| 700 | 1 | |a Baidaliuk, Artem |4 aut | |
| 700 | 1 | |a Favier, Anne-Laure |4 aut | |
| 700 | 1 | |a Enfroy, Cécile |4 aut | |
| 700 | 1 | |a Holy, Xavier |4 aut | |
| 700 | 1 | |a Lourenco, Jérémy |4 aut | |
| 700 | 1 | |a Khoury, Rhéa |4 aut | |
| 700 | 1 | |a Nolent, Flora |4 aut | |
| 700 | 1 | |a Grosenbach, Douglas W. |4 aut | |
| 700 | 1 | |a Hruby, Dennis |4 aut | |
| 700 | 1 | |a Ferrier, Audrey |4 aut | |
| 700 | 1 | |a Iseni, Frédéric |4 aut | |
| 700 | 1 | |a Simon-Loriere, Etienne |0 (orcid)0000-0001-8420-7743 |4 aut | |
| 700 | 1 | |a Tournier, Jean-Nicolas |4 aut | |
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